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12 Cards in this Set
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what tyoe of drugs bind best to albumin?
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hydrophobic
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neonates have incomplete tubes with in the the kidney. this is a problem because it leads to easier overdose because drugs cannot get out.
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blank
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probenacid:
what does it do at low dose what does it do at high dose |
at low dose it causes uric acid retention
at high dose it causes uric acid secretion |
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what phenomenon might you see when starting a regimen of probenacid?
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at first it will cause uric acid retention bc no a lot of drug is on board yet but ill eventually hit the mark where you have enough and you start to excrete uric acid as intended.
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what is the clinical use for probenacid?
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uric acid excretion.
Gout |
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drugs that inhibit p450 may causes what?
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an increase risk of overdose/not as much of other drugs that use p450 get metabolized
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drugs that enhance p450 may cause what?
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increased risk of less drug on board so you do not have enough drug on board as you may intend.
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where are renal transporters located in the kidney?
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PCT
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What is pneumonic for drugs that are easily displaced from albumin?
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Serum proteins can spew
Sulfonamides phenybutazone coumadin sulfonylurase |
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what is the pneumonic for drugs that induce p450?
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one pharmacutical brings about rapid liver metabolism
OCP phenytoin barbituats alcohol rifampin L-Dopa methadone |
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what is the pneumonic for drugs that inhibit p450
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some pharmacutical classes inhibit drug catabolism
sulfonamides probenacid chloramphenicol Isoniazid Dicumarol Cimetadine |
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what is the pneumonic for drugs that use renal trasnporters
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some pharmacuticals plus urate stop trasnpoters
sulfonamides probenacid peni urate salicylates thiazides |
