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9 Cards in this Set
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- Back
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What is the difference between addiction and physical dependance?
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Addiction is a mental disorder, i.e. a psychological dependance. A person can be addicted to a variety of things. A physical dependance starts when tolerance (cell changes) begins. Often occur independantly from one another.
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What are the three major characteristics of addiction?
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compulsive
much time invested (thinking, doing, getting $) high rate of relapse |
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Describe a typical withdrawal reaction.
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Opposite effects to that of drug. Range in severity depending upon:
amount used/day length of use time of withdrawal |
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With regards to teratogenicity, define "selectivity".
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They interfere with fetal development at doses that do not damage the placenta or maternal function.
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Name two drugs commonly found to cause birth defects:
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Accutane
Thalidomide > Phecomelia |
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When is the fetus most sensitive to teratogens?
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3rd week to the 3rd month. Before this = spontaneous abortions, after this = organogenesis complete.
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A single teratogen can produce _____ defects, while many teratogens can produce ______ defects.
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one can produce many defects while many can produce the same one.
e.g. rubella > several malformations |
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Do animal studies accurately predict human teratogenicity?
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No, animal studies are not useful.
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What do FDA Teratogenic categories A,B,C,D,X stand for?
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A> no fetal risk
B> starts to show in animal studies C> some fetal risk D> risk shown in humans X> risk clearly shown |
