Stem Cell and Gene Therapy

By jlammers, Mar 2012

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What are the 3 types of hematopoietic transplants?	Bone marrow, peripheral blood, cord blood
What are the major challenges that must be overcome for successful stem cell therapy?	Seed Threshold: quantity of viable stem cells must be large enough or the transplant will fail. Cell Culture Expansion: need to prevent differentiation of the stem cells when expanding them in culture so they remain useful. Immunogenic rejection Development of a secondary cancer: since stem cells are rapidly dividing. Infection from a contaminated transplant
What is one way cell differentiation is controlled when growing stem cells in culture in preparation for transplant?	Growth factors
How can immunogenic rejection chances be minimized?	use autologous cells (cord cells!) histocompatability matching if need to use an external donor

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