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32 Cards in this Set
- Front
- Back
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Tyramine
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indirect agonist (causes diffusion of norepinephrine)
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Amphetamine
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indirect agonist (causes diffusion of norepinephrine)
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Cocaine
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Blocks uptake 1 (neuronal uptake, counteracts indirect agonists)
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Reserpine
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Blocks vesicular uptake of dopamine (counteracts indirect agonists)
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Ephedrine
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Mixed agonist
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Phenylephrine
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alpha 1 agonist
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Norepinephrine
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alpha 1, alpha 2, beta 1 agonist
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Epinephrine
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alpha 1, alpha 2, beta 1, beta 2, beta 3 agonist
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Dobutamine
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beta 1 agonist (raise HR and contractility w/out changing TPR)
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Terbutaline
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beta 2 agonist (useful in asthma)
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Dopamine
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alpha 1 and beta 1 agonist
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Clonidine
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alpha 2 agonist (prevents release of NE by binding to the alpha 2 autoreceptor on nerve terminal)
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Prazosin
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alpha 1 blocker
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Tamsulosin (Flomax)
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alpha 1 blocker (relieve urinary retention in BPH)
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Phenoxybenzamine
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NON-COMPETITIVE alpha 1 blocker
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Yohimbine
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alpha 2 blocker
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Phentolamine
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alpha 1 and alpha 2 blocker
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Metoprolol
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beta 1 blocker
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Atenolol
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beta 1 blocker
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Butoxamine
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beta 2 blocker
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timolol
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beta 1 and beta 2 blocker
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Propanolol
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beta 1 and beta 2 blocker
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Labetalol
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Mixed antagonist. blocks both alpha and beta
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Alpha 1 (mechanism, location, actions)
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increase IP3, increase DAG
Most VSM - contraction Pupillary dilator - contraction (dilates pupil) Pilomotor SM - erects hair Prostate - Contraction Heart - Increases for of contraction |
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Alpha 2 (mechanism, location, actions)
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Decrease cAMP
Postsynanptic CNS adrenoreceptors - inhibit release of NE (only thing hightlighted in class) |
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Beta 1 (mechanism, location, actions)
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increase cAMP
Heart - increase force and rate of contraction |
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Beta 2 (mechanism, location, actions)
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increase cAMP
Resp, uterine, anf vascular SM - promotes relaxation |
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Beta 3 (mechanism, location, actions)
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increase cAMP
Fat cells - activate lipolysis |
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D1 (mechanism, location, actions)
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increase cAMP
Renal smooth muscle - dilates renal BVs |
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D2 (mechanism, location, actions)
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decrease cAMP
nerve endings - modulates transmitter release |
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Methoxamine
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alpha 1 agonist
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Albuterol
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beta 2 agonist (good for asthma)
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