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9 Cards in this Set
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What is the source of inorganic aresnic?
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the use has been declining
seen in ant and roach baits wood presevatives insecticides milk from poisinsed cows plants comes in 3 oxidative states -elemental -trivalent (aresenite) -pentavalent (arsenate) |
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What is the toxicity of inorganic arsenic?
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the lethal oral dose in mostspcies is 1-25mg/kg
herbivores are more susceptible swine and chickens are rarely poisoned inorganic trivalent is more toxic than pentavalent pentavalent is contered intp trivalent in vivo |
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What is the toxicokinetics of inorganic arsenic?
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aborbed from GI tract, intact skin and by inhalation
distributed all over the body poorly crosses BBB pentavalents is reduced in the liver to trivalent partly metabolized in the liver and kidney by methylation rapid excretion in the urine |
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What is the mechanism of action in in organic arsenic?
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trivalent binds to 2-SH groups of lipoic (thioctic acid)
lipoic acid is essentiap cofactor for the enzymatic decarboxylation of keto acids inhibition of lipoic acid inhibts or slows glycolysis and citric acid locally corrosive pentavalents uncouples oxidative phosphorylation |
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What are the clinical signs of inorganic arsenic?
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peracute - sudden death or severe colic, collapse and death
acute - rapid onset, severe colic, salivation, vomiting, diarrhea, hematuria subacute- colic, anorexia, depression diarrhea with blood, partial paralysis |
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What are the lesions associated with inorganic arsenic?
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GI mucosal edema and hemorrhage sith sloughing and perforation, liver and kidney damage
microscoping capillary degeneration skin exposure causes skin leasions and blistering |
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How do you laboratory diagnose inorganic arsenic?
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chemical analysis - urine
liver and kidney - post morteum GI contents increaed PCV and BUN |
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How do you treat inorganic arsenic?
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emergency and supportive treatment includeing fluids and electrolyits +/- blood transfusion
treatment of acidosis vitamins, antibiotics, analgesics decontamination celation |
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What is the prognosis of inorganinc arsenic toxicosis?
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grave if not treated early
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