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17 Cards in this Set
- Front
- Back
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What are 3 nuclear transcription factors associated with Th1 cells?
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T-bet
STAT-4 STAT-1 |
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What is the "master regulator" of Th1 cell development?
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T-bet
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What are 4 nuclear transcription factors associated with Th2 cells?
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GATA-3
MAF STAT-6 NFAT |
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What is the "master regulator" of Th2 cell development?
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GATA-3
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What are 2 nuclear transcription factors associated with Th17 cells?
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ROR-gamma-t
STAT-3 |
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What is the "master regulator" of Th17 cells?
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ROR-gamma-t
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What is the "master regulator" of thymus-derived nTreg cells?
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FOXP3
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What are 3 primary functions of T-bet?
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"Master regulator" of Th1 cells
Potentiates production of IFN-gamma Suppresses Th2 and Th17 development |
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What is the primary function of STAT-4?
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Production of IFN-gamma
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What are the 2 primary functions of STAT-1?
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Increases production of T-bet
Negative regulation of Th17 |
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What are the 3 primary funcitons of GATA-3?
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"Master regulator" of Th2 cells
Potentiates IL-4 expression Suppresses Th1 cytokines |
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What are the 2 primary functions of MAF?
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Contributes to IL-4 production
Inhibits IL-17 production |
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What are the 2 primary functions of STAT-6?
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Promotes Th2 differentiation
Negative regulator of T-bet and Th1 differentiation |
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What is the primary function of NFAT?
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Increases production of IL-4
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What is the primary function of ROR-gamma-t?
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"Master regulator" of Th17 differentiation.
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What is the primary function of STAT-3?
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Th17 differentiation
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What is the primary function of FOXP3?
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"Master regulator" of thymus-derived nTreg cells
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