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36 Cards in this Set
- Front
- Back
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active transport
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uses energy to move solutes AGAINST their concentration gradient
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uniport
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only transport one substrate
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symport
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coupled transport of two substrates in same direction
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antiport
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coupled transport of two substrates in opposite direction
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In active transport, shape change requires___
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energy
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Primary active transport
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uses ATP as eneryg source-ATPases or pumps
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Na+-K+-ATPase
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primary active transport:
maintains the concentration gradients of Na+ and K+...3Na out to 2K in, 1 AtP.. source of potential energy |
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secondary active transport
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couples energy of one molecule moving down its concentration gradient with another molecule moving against its concentration gradient.
can be symport or antiport |
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How is energy directed into the Na K ATPase?
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3 na+ dependent phosphorylation, followed by 2K dependent dephosphorylation
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membrane potential
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difference in positive charges between the inside and outside of cell
pump stoichiometry of 3/2 is electrogenic |
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In an ion pump, Pi is transferred from ATP to the _____ forming a high energy anhydride linkage
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carbyoxyl of a Glu or Asp residue..
later the phosphate is released by hydrolysis |
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ER Ca2+ pump is called
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SERCA: sarcoendoplasmic reiculum Ca2+ ATPase
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primary active transporter show substrate ___
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saturation
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Vmax
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50% maxiaml rate at physiological substrate concentration
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P-type
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phosphorylation site
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v-type
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vacuole type for acidification of lysosomes, endosomes, golgi, and secretory vesicles
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inner membrane ATPase to regulate H+ and adjust proton gradients is what type of transporter?
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v-type
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f-type
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energy coupling factor. like ATP synthase
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ABC transporter
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ATP-binding Cassette protein for active transport of heavy metal ions and chemicals
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indirect active transport
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transporter uses a ion gradient that was caused by energy from a different transporter
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ATPase creates
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ion gradient
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What is a Na-coupled D-glucose transporter?
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secondary active symporter
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NKCC
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Na+/K+/2Cl- secondary symporter ...
reuptake of Na+ in kidney |
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Na+/H+ exchanger
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secondary active antiporter
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Na+/glucose cotransport
how does glucose go into the cell? |
when the Na+ is released inside, it causes glucose release to inside
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In a Na+/glucose cotransport, what stimulates glucose binding?
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bound Na+
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What are the 3 transport systems of calcium thru the membrane?
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in:
Ca-channel out: Ca-ATPase Ca-Na Antiport coupled with Na-K-ATPase |
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ouabain inhibits what?
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na+-K+-ATPase
however, in low concentrations, ouabain can stimulate the transporter...therefore digoxin (Lanoxin) is used |
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Anion antiport in parietal cells of stomach with H+-K+-ATPase to produce what?
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stomach acid - HCl is the product in the stomach luman
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omeprazole inhibits what?
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the H+-K+-ATPase directly
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cimetidine
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inhibits HK-ATPase activation by histamine receptor becaus it resembles a histamine
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Secondary active transports allow substrates to move which way in respect to the gradient
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UP or DOWN
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secondary active transporters require what kind of energy?
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concentrative-indirect input to move up the gradient
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'loop' diuretics inhibit what?
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NKCC
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amiloride inhibits what?
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Na/H antiport
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electrochemical gradient is caused by
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chemical force and electrical force
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