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Retinoblastoma
Rb gene--tumors arise when both alleles are non-functional

location: 13q


Causes unregulated E2F activity leading to unregulated cell cycle progression

Tumors: Retinoblastoma and Osteosarcoma
Li-Fraumeni
p53 mutation

Location: 17p
Oncogene associated with Burkitt Lymphoma
c-myc
Tumor supressor gene associated with Melanoma
p16

Location: 9p
cancers arise when both alleles are non-functional
APC
tumor supressor gene associated with colorectal cancer

location: 5q
BRCA 1 & 2
Breast and ovarian cancer
17q, 13q
Tumor supressor gene associated with Wilm's tumor

location on chromosome
WT1
11q
Tumor supressor gene associated with Neurofibromatosis 1 & 2

location on chromosome

function
NF1 & NF2

17q & 22q

NF 1 encodes GTPase activating protein that decreases activity of Ras (signaling molecule in cell proliferation
Tumor supressor gene associated with Pancreatic Cancer

location on chromosome
DPC
18q
Tumor supressor gene associated with Colon Cancer

location on chromosome
DCC
18q
Oncogene associated with CML
abl
Oncogene associated with Follicular and undifferentiated lymphomas
bcl-2

antiapoptotic-antagonist of apoptic cell death--when bcl-2 is upregulated--cells won't die and are prone to malignant transformation

t(14;18) follicular lymphoma
t(14;18)
Oncogene associated with Breast, Ovarian and Gastric Carcinomas
erb-B2
L-myc
Oncogene associated with Lung Tumor
Oncogene associated with Neuroblastoma
N-myc
Multiple Endocrine Neoplasia
type 2 & 3
ret
Tumor Marker for Ovarian Cancer
CA-125

marker for ovarian and malignant epithelial tumors
Tumor Marker for Neuroblastoma, lung and gastric cancer
Bombesin
S100
Marker for melanoma, neural tumors and astrocytoma
tartrate resistant acid phosphatase
hairy cell leukemia & B-lymhocyte neoplasm
carcinoembryonic antigen
very nonspecific but produced by 70% of colorectal & pancreatic cancers. Also gastric and breast but not by ovarian
alpha-feto protein
yolk sack tumors
nonseminomatous germ cell tumors of testis, hepatocellular carcinomas
beta-hCG
hydatidiform moles, choriocarcinomas and gestational throphoblastic tumors