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11 Cards in this Set
- Front
- Back
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Rb
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normally blocks G1-S transition
loss --> retinoblastoma, osteosarcoma |
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p53
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normally blocks G1-S transition
loss --> most cancers, Li-Fraumeni syndrome (germline mutation --> cancer suceptibility) |
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BRCA1
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normally repairs DNA
loss --> breast and ovarian cancer |
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BRCA2
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normally repairs DNA
loss --> breast cancer |
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p16
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loss --> melanoma
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APC
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loss --> familial adenometous polyposis and colorectal cancer
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WT1
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loss --> Wilms' tumor (nephroblastoma)
|
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NF1
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loss --> neurofibromatosis 1
|
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NF2
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loss --> neurofibromatosis 2
|
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DPC
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loss --> pancreatic cancer
|
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DCC
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loss --> colon cancer
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