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12 Cards in this Set
- Front
- Back
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Tumor suppressor genes
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loss of function --> cancer
both alleles must be lost for expression of disease |
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Rb
|
retinoblastoma
osteosarcoma rb gene blocks G1-S phase |
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BRCA1
|
breast and ovarian cancer
DNA repair protein |
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BRCA2
|
breast cancer
DNA repair protein |
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p53
|
most human cancer
Li-Fraumeni syndrome --> one allele delation need a second hit p53 block G1-S phase |
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p16
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Melanoma
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APC
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Colorectal cancer (associated with FAP)
Gardener (osteoma,lipomas) --> lumpy and bumpy everywhere Turncots |
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WT1
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Wilm's tumor
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NF1
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Neurofibramatosis type 1
|
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NF2
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Neurofibramatosis type 2 - bilateral acoustic schwannoma
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DPC
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Pancreatic cancer
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DCC
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colon cancer
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