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20 Cards in this Set

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antidotes for anticholinesterase toxicity (e.g. organophosphates)
atropine
pralidoxime
mechanism of mortality in TCA overdose

treatment of TCA overdose
TCA-induced hypotension

secure ABCs, then give sodium bicarb
treatment of alcohol withdrawal
lorazepam
diazepam
chlordiazepoxide
Signs and Sx of methanol intoxication
h/n/v
optic disc hyperemia
anion gap metabolic acidosis
distinguish between methanol and ethylene glycol poisoning
methanol damages eyes

ethylene glycol damages kidneys
TCA overdose signs and Sx
hyperthermia
seizures
hypotension
anticholinergic effects

important! TCA overdose causes QRS widening and risk of ventricular arrhythmia!
phases of iron intoxication

what serum level is toxic?
GI phase (30 min)
latent phase (6-24 hrs)
shock, metabolic acidosis (6-72 hrs)
hepatotoxicity (12-96 hrs)
bowel obstruction 2/2 mucosal scarring (weeks)

>350 mcg/mL
treatment of acute iron poisoning

treatment of acute lead poisoning
deferoxamine

succimer for mild-mod
EDTA for mod-severe
signs and Sx of benzodiazepine intoxication
slurred speech
unsteady gait
drowsiness

pupil sizes normal, mild respiratory depression
treatment for overdose of anticholinergic?
physostigmine, a cholinesterase inhibitor
etiology of torsades de pointes

treatment of torsades de pointes
seen in setting of long QT interval (familial LQT syndrome, hypomagnesemia, TCA intox, amiodarone and sotalol intox, moxiflox and fluconazole intox)

cessation of offending agent + magnesium sulfate
treatment of ethylene glycol poisoning
fomepizole or ethanol to bind alcohol dehydrogenase
treatment of beta-blocker overdose
atropine + IV fluids

glucagon if unsuccessful
fluphenazine (typical antipsychotic) unusual side effect
hypothermia by inhibiting body's shiver mechanism
options for NMS if dantrolene not available
bromocriptine
amantadine
treatment of PCP intoxication
benzos
time before serum acetaminophen is useful in predicting hepatotoxicity
4 hrs (treat with activated charcoal before 4 hours)

administer NAC within 8 hours
treatment organophosphate poisoning
atropine

organiophosphate poisoning inactivates acetylcholinesterase, leading to cholinergic excess; atropine competes with Ach at muscarinic receptors
treatment for a patient with QRS interval >100 msec?
sodium bicarbonate

reverses QRS prolongation by increasing EC Na+ concentration
signs/Sx of beta-blocker overdose
bradycardia
hypotension
(bronchospasm)
(hypoglycemia)

may lead to cardiogenic shock