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15 Cards in this Set
- Front
- Back
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nicotine
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nAChR agonist at ganglion and NMJ
smoking cessation SE: hypertension, tachycardia, nausea, vomiting, diarrhea, Seizures, Nausea |
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DMPP (Dimethylphenyl piperazinium)
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nAChR agonist at ganglion, stimulates E/NE release in adrenals
Int: HR and BP effects blocked by hexamethonium |
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Acetylcholine
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mAChR and nAChR agonist
AChE sensitive cataract and eye surgery SE: PS effects |
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Methacholine
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mAChR agonist
AChE sensitive diagnosis of airway hyperreactivity SE: PS effects |
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Bethanechol
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mAChR agonist
AChE insensitive increase bladder and bowel activity SE: PS effects, Vasodilation, reflex tachycardia, sweating |
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Carbachol
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mAChR and nAChR agonist
AChE insensitive eye surgery (induces miosis) and glaucoma SE: PS effects |
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Muscarine
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mAChR agonist
no clinical use SE: PS effects |
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Pilocarpine
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mAChR agonist >> nAChR
Dry mouth, Sjogren's syndrome SE: PE effects, vasoconstriction, reflex tachycardia, sweating |
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Cevimiline
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M3 selective agonist
Dry mouth, Sjogren's syndrome, glaucoma SE: PE effects |
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McN-A-343
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M1 selective agonist
not used clinically, has sympathetic effect SE: PE effects Int: Selectively blocked by pirenzepine or atropine |
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Edrophonium
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AChE inhibitor
noncovalent, short acting. Used for Myasthenia Gravis diagnosis. |
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Neostigmine
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AChE inhibitor
carbamate, medium to long acting, no CNS penetration Used to treat MG SE: overdose causes desensitization (cholinergic crisis) |
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Physostigmine
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AChE inhibitor
carbamate, medium to long acting, CNS penetration reversal of severe atropine poisoning, acute glaucoma SE: seizures |
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organophosphates (isofluorophate, echothiophate)
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AChE inhibitor
covalent, very long acting. Glaucoma |
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Donepezil
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AChE inhibitor
Allosteric inhibitor Alzheimer's SE: Nausea, vomiting |
