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17 Cards in this Set
- Front
- Back
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Hepatitis A
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acute infection only
flu like symptoms in adults often asymptomatic in children usually travelers - fecal oral route problem in people with chronic liver disease vaccine |
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Hepatitis E
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severe acute hepatitis - no chronic infection
more severe than Hep A 20% mortaility among pregnant women often see in outbreaks |
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Hepatitis B
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DNA virus (only one of the hepatitis viruses)
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Hepatitis B Core Ab IgM
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indicates acute HBV
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Hepatitis B Surface Ag
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indicates infection (acute or chronic)
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Hepatitis B Surface Ab
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indicates immunity to Hep B
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Hepatitis B E Ag
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indicates active replication (and usually active hepatitis)
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Hepatitis B E Ab
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seroconversion
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Hepatitis B DNA
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high titer correlates with viral activity and risk for hepatocellular carcinoma
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perinatally acquired chronic HBV
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Surface Ag+
high serum HBV DNA ALT is normal HBx - minimal inflammation can serocovert: E Ag-, E Ab+, low HBV DNA |
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adult acquired chronic HBV
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S Ag+, E Ag+, high serum HBV DNA
elevated ALT, HBx-, active inflammation |
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inactive (carrier) chronic HBV
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S Ag+ > 6months
E Ag-, E Ab+ ALT normal low HBV DNA |
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HBeAg- chronic hepatitis
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mutant virus that doesnt produce E Ag
E Ag-, E Ab +/-, S Ag+ high serum HBV DNA, elevated ALT, active inflammation |
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Hepatitis D
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Needs concurrent HBV infection - for viral coating
coinfection and superinfection - more sever hepatitis |
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causes of acute hepatitis in HBsAg+ person
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acute HBV infection
Superinfection seroconversion HBeAG-> anti-Hbe HBV reactivation non-viral liver injury |
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Hepatitis C
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most often becomes chronic viral hepatitis
route of infection - blood - tatoos, needles (not usually sexual) EtOH and HCV dmg is synergistic |
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Hepatitis B labs
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acute infection see HCV RNA
HCV Ab to diagnosis ALT will go up and down |