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7 Cards in this Set
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def - Pathogenesis
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mode of development of disease
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def - Virulence
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capacity to cause disease
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def - Attenuation
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loss of virulence
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Disease Triad
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1) pathogen or agent causing disease (virulence factors)
2) host 3) environment e.g. Hantavirus pulmonary syndrome |
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What agent factors determine viral disease?
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viral strain (virulence), route of infection, dose of virus
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What host factors determine viral disease?
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species, age, genetic susceptibility, immune status
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Cell Tropism
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1) spectrum of tissues/cells that may be infected by a virus
2) virus receptor (host cell protein) determine trophism 3) cell state (replication cycle is important in determining what kind of infection occurs |
