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treatments for diarrhea
narcotic option?
opioids
diphenoxylate

loperamide
treatments for diarrhea
antisecretory option?
antisecretory agents
Bismuth
Subsalicylate
Bismuth
Subsalicylate
treatments for diarrhea
a) opioids

b) antisecretory agents
a)
diphenoxylate
loperamide

b)
Bismuth
Subsalicylate
Mechanism of action for opioids:
•induces sustained segmental contraction of intestinal smooth muscle

•prevents normal parastalsis

•activation on opioid receptors in smooth muscle


Potential adverse effects:?
• constipation
Mechanism of action for

antisecretory agents:
•inhibits intestinal secretions

Indications:?
Potential adverse effects:?
•infectious diarrhea

A/E:
•Rarely any
•excessive doses can cause
bismuth or salicylate toxicity
Histamine H2-receptor antagonists
3ct



Gastric Antacids 1ct


prokinetic drugs 1ct
cimetidine
famotidine
ranitidine


Calcium Carbonate

Metoclopramide
Nm Class:

ONDANSETRON
PROCHLORPERAZINE
METOCLOPRAMIDE
DRONABINOL
PROMETHAZINE
SCOPOLAMINE
Class:

~Seritonin 5ht3 Antagonist~

-PHENOTHIAZINES
-D2 Antagonist (Prokinetic)
-MARIJUANA DERIVATIVE
-ANTIHISTAMINES H1
-Muscarinic Recept Antagonist


Nm Rx-s: ?
6ct
ONDANSETRON
PROCHLORPERAZINE
METOCLOPRAMIDE
DRONABINOL
PROMETHAZINE
SCOPOLAMINE
Metoclopramide

Potential adverse effects:
6ct
CNS effects such as

-Drowsiness
-Extra-pyramidal effects
-Seizures
-Hyperprolactinemia
-Diarrhea
-Hematologic toxicity


Potential adverse effects:for what Rx?
Metoclopramide
Metoclopramide

Indications::
4ct
-Antiemetic
-Diabetic Gastroparesis
-GERD
-Intractable Hiccups

Indications for what Rx:
Metoclopramide
Sucralfate Blocks
4ct
~Digoxin
~Florquinolones
~Ketconozole
~Phenytoin


these Rx-s are blocked by
Nm Rx 1ct
Sucralfate