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12 Cards in this Set
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complications in wound healing?
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-deficient scar formation
-excessive formation of repair components: keloid scars -formation of contractures - exaggerated contraction of wound |
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systemic factors retarding wound healing
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-nutrition: vitamin c
-metabolic status: diabetes -circulatory status: retarded venous drainage -hormones: glucocorticoids (inhibit collagen syn) |
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local factors retarding wound healing
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-infection
-mechanical -foreign bodies -size/location/type |
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first intention
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-clean, uninfected surgical incision
-re-epithelialization to close wound -thin scar |
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second intention
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-wound creates large defect on skin
-big loss cells/tissue -large scar |
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Inflammation: involves? time?
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-RBC + fibronectin + fibrin + complement components
-w/in 24 hrs |
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granulation
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-24-72 hrs into
-angiogenesis/proliferation of fibroblasts form gran tissue -more granulation tissue w/more intensity of wound/inflammation |
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wound contraction
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-w/large surface wounds
-myofibroblasts express smooth muscl alpha-actin -contract wound tissue |
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fibroblast migration
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-driven by chemokines/cytokines
-48-96 hrs in |
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epithelialization
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-close wound from dermis outward
-collagen fibrils bridge incision |
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fibrosis
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-excessive deposit of collagen/other ECM
-usually in chronic disease |
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wound strength
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-dependent on net collagen accumulation
-more tensile strength after 2 months + cross-linking |
