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What are the 2 subcategories in the family of azole oral antifungal drugs?
1) Triazoles
2) Imidazoles
What are the 2 triazole antifungals?
1) Itraconazole
2) Fluconazole
What is the main imidazole anti fungal drug?
Ketoconazole
What 2 drugs are in the Allylamine group of antifungals?
1) Terbinafine
2) Naftifine
What are the 2 major groups of oral antifungals?
1) Azoles
2) Allylamines
What is the bioavailibility of oral Terbinafine?
40%
What is the bioavailibility of oral Itraconazole?
55%
What is the bioavailibility of oral Fluconazole?
90%
What is the trade name for Terbinafine?
Lamisil
What is the trade name for Itraconazole?
Sporanox
What is the trade name for Ketoconazole?
Nizoral
What are the 5 main systemic anti fungal drugs used in dermatology?
1) Terbinafine
2) Itraconazole
3) Fluconazole
4) Griseofulvin
5) Ketoconazole
Terbinafine and other Allylamines are fungicidal by inhibiting what enzyme?
Squalene Epoxidase
Inhibition of squalene epoxidase by Terbinafine and other allylamines leads to accumulation of what and subsequent deficiency of what?
Accumulation of Squalene
Subsequent deficiency of Ergosterol
The triazoles, Itraconazole and Fluconazole both inhibit the cytochrome P-450 enzyme...
Lanosterol 14-alpha demethlyase
The triazoles, Itraconazole and Fluconazole exert their fungistatic action by inhibiting Lanosterol 14-alpha with resultant inhibition in the conversion of what to what?
Lanosterol to Ergosterol
Terbinafine is FDA approved for treatment of adults with what?
Dermatophyte onychomycosis of the toenails and finger nails
This systemic anti fungal is FDA approved for treatment of adults with dermatophyte onychomycosis of toe or fingernails, and for systemic mycoses like blast, histo and aspergillosis.
Itraconazole
Fluconazole is FDA approved for treatment of what 3 conditions?
1) Vaginal Candidiasis
2) Oropharyngeal and Esophageal Candidiasis
3) Cryptococcal meningitis
When treating dermatophyte oncychomycosis what are your 3 best options for oral antifungals?
1) Terbinafine
2) Itraconazole
3) Fluconazole