xexam4 mfm75 Flash Cards

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Title: xexam4 mfm75
Description: Hexose Monophosphate Shunt exam4 mfm75 dcom
Number of Cards: 16
Save Count: 0
Author: divakarendenise9
Created: 2007-11-24
Tags: dcom exam4 mfm75
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    • Question
    • Answer
    • Side 3
    • transketolase and transaldolase are in the ... pathway and are mainly in what type of cell:
    • pentose phosphate
      RBC
    • what 3 things are important about the HMP pathway:
      1.
      2.
      3.
    • 1. produces NADPH for other reactions
      2. nucleotide biosynthesis
      3. transketolase activity
    • 1. NADH is for:
      2. NADPH is for:
    • 1. electrons for energy
      2. electrons for reductive biosynthesis
    • if transketolase activity is down then it is due to ...
    • thymine pyrophosphate deficiency (TPP)
    • in the liver, what is necessary to generate an NADPH
    • G6PDH
    • in the liver, what is the pathway that creates NADPH:
    • glucose-6-phosphate to pentose phosphates
    • NADPH helps in the metabolism of certain classes of ...
    • drugs - hydrophobic
    • what enzyme is important for metabolizing drugs:
    • p450 enzymes
    • do p450 enzymes induce or inhibit drugs:
    • both
    • what are the 3 uses we need NADPH and where:
      1.
      2.
      3.
    • 1. drug metabolism in the liver
      2. kill bacteria with reactive oxygen species in neutrophil
      3. to remove H202 from erythrocytes
    • what happens of hydrogen peroxide accumulates in the RBC:
      1.
      2.
    • denaturation of hemoglobin (Heinz bodies)
      hemolytic anemia from membrane damage
    • glutatione peroxidase reduces ... to ...
    • hydorgen peroxide
      water
    • glucose-6-phosphate dehydrogenase deficiency means you cannot make ...
    • NADPH
    • if you have normal 2,3-BPG levels and high Heinz bodies levels, this is indicative of ... and can be developed from eating ...
    • glucose-6-phosphate dehydrogenase deficiency
      fava beans
    • what can bring on a bout of acute hemolytic episodic anemia:
      1.
      2.
      3.
    • 1. drugs
      2. food (fava beans)
      3. overwhelming infection
    • thiamine deficiency is detected by measuring ... in RBC
    • transketolase