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23 Cards in this Set

  • Front
  • Back
Epitotes are *** *** regions of an antigen.
immunologically active
All antibodies bind ***, T-cell receptors recognises only ***.
antigens
processed antigens
Antibodies are found as membrane bound constituents of *** and molecules secreted by ***.
B-cells
plasma cells
Antibody proteins are collectively called ***.
immunoglobins(Igs)
*** is the ability to induce a humoral and/or cell mediated immune response.
Immunogenicity
*** is the ability to combine
specifically to antibody and or surface
receptors on T cells.
Antigenicity
Not all antigens can be immunogenic
e.g. ***
haptens
Properties of the Immunogen contribute to immunogenicity... examples.
Foreignness
Molecular size
Chemical composition & complexity
Susceptibility to antigen processing
How many daltons generally make an immunogenic immunogen?
100k+ daltons
***polymers lack immunogenicity. ***polymers are more immunogenic.
Homo
Hetero
***, such as ***, when mixed
with antigen enhances the
immmunogenecity.
Adjuvants
Alum
B and T cells recognise *** epitopes on the same antigenic molecule.
different
Two light chains of # Kda, identical.
Two heavy chains of # KDa or more, identical.
22
55
Light chains bound to heavy chains by a *** bond and *** interactions.
disulfide
noncovalent
Light chain - *** region (110 amino acids) is variable region (***) and *** is constant region (***).
N-terminal
LV
C-terminal
LC
Two light chain types
– *** - 60% in humans
– *** – 40%
Kappa
Lambda
Length 330 amino acids for ***, ***, and *** heavy-chains. 440 amino acids for *** and ***.
delta, gamma, and alpha
mu and epsilon
IgG
Heavy chain?
Light chain?
γ
λ or κ
IgM
Heavy chain?
Light chain?
μ
λ or κ
IgA
Heavy chain?
Light chain?
α
λ or κ
IgE
Heavy chain?
Light chain?
ε
λ or κ
IgD
Heavy chain?
Light chain?
δ
λ or κ
Allergens that bind to Ig*** release ***.
E
histamines