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14 Cards in this Set
- Front
- Back
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*** receptors only recognize antigen that are processed and presented in the context of MHC.
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T-cell
|
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APC?
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Antigen-presenting cell
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Class I MHC molecules: are *** expressed on surface of all ***
cells; presents antigens to *** cells |
glycoproteins
nucleated Tc |
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Class II MHC molecules are *** expressed on the surface of ***;
present antigens to *** cells |
glycoproteins
APC Th |
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Class III MHC molecules are proteins involved in ***, such as ***.
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immunity
inflammation |
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Class I MHC molecules consist of two protein chains. Longer chain is *** (### kDa) and is *** linked to *** (### kDa).
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α-chain(α1, α2, α3)
45 noncovalently β2 microglobulin 12 |
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Class II MHC molecules consists of two protein chains: *** (### kDA) and *** (###
kDa). |
α-chain(α1, α2)
22 β-chain(β1, β2) 28 |
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Class *** MHC are primarily found on the cells of the immune system like ***, *** and ***.
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II
Monocytes/macrophages and B-cells |
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Class *** MHC can deliver *** signals while the others can't.
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II
intracellular |
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Some MHC loci in human have *** alleles.
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over 100
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Gene TAP encodes ***.
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Peptide-transporter subunits
Transporter Associated with antigen Processing |
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Gene TNF encodes ***.
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tumor necrosis factors
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Cells that display MHC I peptides to *** cells are referred to as *** cells.
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CD8+ Tc
target |
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Cells that display MHC II peptides to *** cells are called ***.
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CD4+ Th
antigen-presenting cells (APC) |
