- Shuffle
Toggle OnToggle Off
- Alphabetize
Toggle OnToggle Off
- Front First
Toggle OnToggle Off
- Both Sides
Toggle OnToggle Off
Front
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
PLAY BUTTON
PLAY BUTTON
3 Cards in this Set
- Front
- Back
|
Jaundice: Where do most of the bilirubin come from?
|
85% of daily production (0.2-0.3gm) from senescent RBC breakdown by macrophages in spleen, liver, and bone marrow.
The rest (15%) comes from: turnover of hepatic heme, hemoproteins (P450s etc.), or premature destruction in bone marrow. |
|
Jaundice:
Differentiate between unconjugated and conjugated bilirubin. |
Unconjugated bilirubin
- Exists as tightly-bound albumin complexes - Cannot be excreted in urine (even at high levels). - A small amount of albumin-free unconjugated bilirubin exists in plasma (toxic to tissues) Conjugated bilirubin (bilirubin glucoronides) - Water-soluble, - Nontoxic - Loosely bound to albumin. - Can be freely excreted in urine |
|
MECHANISM: Jaundice
|
Jaudice is evident when plasma levels rise above 2.0-2.5mg/dL
(normal is 0.3 - 1.2mg/dL). Jaudice occurs in 1) Excessive hepatic production of bilirubin, 2) reduced hepatocyte uptake, 3) impaired conjugation, = High unconjugated bilirubin 4) decreased hepatocellular excretion, 5) impaired bile flow. = High conjugated bilirubin |
