Y2B3 Pharm- Antiviral agents Flash Cards

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Title: Y2B3 Pharm- Antiviral agents
Description: Some clue words to associate w/ drugs
Number of Cards: 26
Save Count: 0
Author: Gabbles14
Created: 2011-12-13
Tags: do14 pharm touro
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    • Question
    • Answer
    • Side 3
    • Crystallizes in Kidney
    • Acyclovir

      therefore you dose it based on Ideal weight and renal fxn
    • DOC for CNS, visceral and disseminated infections
    • Acyclovir
    • Acyclovir resistant VZV use?
    • Foscarnet
    • thymidine kinase intermediate
    • Acyclovir
    • Only PO, no HSV encephalitis and primary varicella and activated to pencyclovir
    • FAmciclovir
    • Only PO w/ better bioavailability d/t blood levels being 3-5x higher than w/ another drug in this family.
    • Valcyclovir

      Used as a step down therapy for acyclovir. IV acyclovir --> PO valcyclovir
    • tx of keratojuncitivitis
    • trifluride

      cannot be used systemically because it irreversibly inhibits thymidine synthase in both our DNA and viral DNA
    • acyclovir resistance
    • 1)virus decreases TK (virus gets smart and doesn't phosphorylize the prodrug)
      2) altered DNA polymerase enzymes
      3) altered substrate specificity
    • DOC for CMV
    • Gancyclovir
    • SE include: teratogenicity, carcinogenicity, mutagenicity.
    • Ganciclovir
      Valganciclovir (+ anemia and diarrhea)
    • Oral levels of this drug are equal to IV levels of Ganciclovir.
    • Valgancyclovir (PO only)
    • HSV and VZV resistance and directly inhibits DNA polymerase
    • Foscarnet

      2nd line CMV
      se: BMS, nephro and electrolyte disturbances.
    • Tx HSH and VZV and has a very long intracellular half life. You can give the pt one dose once a week.
    • Cidofovir

      SE: BMS, nephro, metabolic acidosis
    • Start this neuramidase inhibitor w/n 36 hrs of infection
    • Oseltamivir (PO)
    • Neuropsychiatric SE
    • Oseltamivir
    • Start this neuramidase inhibitor w/n 48 hrs of infection
    • Zanamivir ( inhalation)
    • Death caused by bronchospasms in asthmatics
    • Zanamivir
    • SE: flu like sxs for the 1st couple of days until the body acclimatizes
    • Hep C- interferon products
    • RSV
    • palivizumab
    • genital and plantar arts
    • imiquimod
    • inhibits GP41 Fusion
    • Enfurvitide
    • SE:mitochondrial toxicity and lipoatrophy
    • NRTIs

      combo: emtricitibine / tenofovir --> most highly recommended drug for HAART
    • HSN to this NRTI can be fatal
    • Abacavir
    • CNS effects
    • Efavirenez (NNRTI)
    • SE: dysglycemia + lipodystrophy + hepatotoxicity
    • Protease inhibitors (atazanavir and darunavir)
    • Integrase inhibitor
    • raltegravir