looked at how age impacted functional connectivity through the comparison of early and late-onset AD patients to 2 age-matched groups (young and old). The differences in functional connectivity were examined through resting state fMRI comparisons on 20 early-onset (65 years) AD patients, and 15 “young” (65 years) age matched control groups. The differences in connectivity were examined through 8 resting state networks and 5 cognitive domains[1]. They found that early-onset AD patients showed lower functional connectivity compared to the “young” age-matched controls in all 8 RSNs and late-onset AD patients showed lower functional connectivity compared to the “old” age-matched controls in 2 of the 8 RSNs. Functional connectivity was lower in early-onset compared to late-onset AD in auditory-, sensory-motor, dorsal-visual systems and the default mode network. Overall they came to the conclusion that functional organization was more disrupted in early-onset AD patients when compared with late-onset AD patients. However, they warned that the sample from this study was small and from similar locations so it really wasn’t meant to be seen as a trend across all Alzheimer’s
looked at how age impacted functional connectivity through the comparison of early and late-onset AD patients to 2 age-matched groups (young and old). The differences in functional connectivity were examined through resting state fMRI comparisons on 20 early-onset (65 years) AD patients, and 15 “young” (65 years) age matched control groups. The differences in connectivity were examined through 8 resting state networks and 5 cognitive domains[1]. They found that early-onset AD patients showed lower functional connectivity compared to the “young” age-matched controls in all 8 RSNs and late-onset AD patients showed lower functional connectivity compared to the “old” age-matched controls in 2 of the 8 RSNs. Functional connectivity was lower in early-onset compared to late-onset AD in auditory-, sensory-motor, dorsal-visual systems and the default mode network. Overall they came to the conclusion that functional organization was more disrupted in early-onset AD patients when compared with late-onset AD patients. However, they warned that the sample from this study was small and from similar locations so it really wasn’t meant to be seen as a trend across all Alzheimer’s