Type 3 Diabetes (T3DM) as proposed by De la Monte:
Type 3 diabetes (T3DM) is a type of neuroendocrine disease that is related to Alzheimer’s disease (AD [95, 96]. T3DM is characterized by insulin resistance in the brain with low levels of insulin and insulin–like growth factor type I and II (IGF-I and IGF-II) and the number of their receptors [99, 100]. There is now sufficient evidence that genetic polymorphisms [101] and endothelial dysfunction leads to a number of functional changes in the vascular