|
Calcium chelator
|
Tetracycline
|
|
|
Brown teeth
|
Tetracycline
|
|
|
Gray-baby syndrome
|
Chloramphenicol
|
|
|
Oto- and nephrotoxicity
|
Vancomycin, aminoglycosides
|
|
|
Optic neuritis
|
Ethambutol
|
|
|
Polyarthralgia
|
Pyrazinamide
|
|
|
Induces cytochrome P450
|
Rifampin
|
|
|
Red-man syndrome
|
Vancomycin
|
|
|
Pseudomembranous colitis
|
Clindamycin
|
|
|
Kernicterus
|
Sulfonamides
|
|
|
Megaloblastic anemia (supplement with vitamin B6)
|
Trimethoprim-sulfamethoxazole
|
|
|
Cartilage damage, tendonitis
|
Fluoroquinolones
|
|
|
Orange bodily fluids
|
Rifampin
|
|
|
Fast vs. slow acetylators
|
Isoniazid
|
|
|
Infusion-related toxicity
|
Amphotericin B
|
|
|
D-Ala-D-Ala
|
Vancomycin
|
|
|
PBP3
|
Aztreonam
|
|
|
Blocks peptidyltransferase
|
Chloramphenicol
|
|
|
Blocks peptide bond formation
|
Clindamycin
|
|
|
Blocks ribosomal translocation by preventing exit of tRNA
|
Macrolides
|
|
|
Inhibits initiation complex, causes mRNA misreading, blocks translocation
|
Aminoglycosides
|
|
|
Blocks tRNA binding to ribosome
|
Tetracycline
|
|
|
Bactericidal for H. flu, S. pneumo, N. meningitidis
|
Chloramphenicol
|
|
|
Blocks initiation step of protein synthesis
|
Linezolid
|
|
|
PABA analogue
|
Sulfonamides
|
|
|
Prevents synthesis of dihydrofolic acid
|
Sulfonamides
|
|
|
Inhibits dihydropteroate synthetase
|
Sulfonamides
|
|
|
Prevents synthesis of tetrahydrofolic acid
|
Trimethoprim
|
|
|
Inhibits dihydrofolate reductase
|
Trimethoprim
|
|
|
Resistance is due to rRNA methylation
|
Clindamycin, macrolides
|
|
|
DNA gyrase, topoisomerase IV
|
Fluoroquinolones
|
|
|
RNA polymerase
|
Rifampin
|
|
|
Inhibits mycolic acid synthesis
|
Isoniazid
|
|
|
Inhibits arabinogalactan synthesis
|
Ethambutol
|
|
|
Inhibits microtubule function
|
Griseofulvin
|
|
|
Inhibits beta(1,3)D-glucan synthetase
|
Caspofungin
|
|
|
Binds ergosterol
|
Amphotericin B, nystatin
|
|
|
Inhibits lanosterol demethylation by cytochrome P450
|
Azoles
|
|
|
Inhibits thymidylate synthase
|
Flucytosine
|
|
|
Used to treat cryptococcal meningitis
|
Flucytosine
|
|
|
Used for meningococcal prophylaxis
|
Rifampin
|
|
|
Used to treat Pseudomonas infection in CF patients
|
Fluoroquinolones
|
|
|
Used to treat nocardiosis
|
Sulfonamides
|
|
|
Used to treat VRE, MRSA, PRSP
|
Linezolid
|
|
|
Used to treat C. perfringens and B. fragilis
|
Clindamycin
|
|
|
Used to treat Mycoplasma pneumoniae
|
Tetracycline
|
|
|
Used to treat chlamydia
|
Tetracycline
|
|
|
Used to treat Legionella
|
Macrolides
|
|
|
Used to treat gonorrhea
|
Ceftriaxone
|
|
|
Used to treat H. flu meningitis
|
Chloramphenicol
|
|
