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53 Cards in this Set
- Front
- Back
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↑ Eosinophil Numbers
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IL 3
IL 5 |
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Th1 release
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IFN γ
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Th2 Release
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IL 4
(+ IL 5 + IL 13) |
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Th17 Release
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IL - 17
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Prostaglandins are made as result of
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Cyclooxygenase Pathway
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Prostaglandins Cause
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↓ Platelet Aggregation
↑ Vasodilation |
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Leukotrienes are made as a result of
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(Leukocytes)
Lipoxygenase Pathway |
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Leukotrienes Cause
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Chemotaxis of Neutrophils
Vasoconstriction ↑ Bronchospasm ↑ Vascular Permeability |
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Serotonins are made as a result of
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Platelets
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Serotonin Causes
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Arteriolar Dilatation
↑ Vascular Permeability |
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Histamine is made by
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Mast Cells
Basophils Platelets |
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Histamine Causes
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Arteriolar Dilatation
↑ Vascular Permeability |
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PAF is made by
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Mast Cells
Eosinophils |
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Lysozyme Is Made By
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Macrophages
Neutrophils |
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Lysozyme Causes
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Lysis of Bacterial Cell Wall
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NO is made by
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Macrophages
Endothelial Cells (from TNF and IFNγ) |
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NO causes
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Vasodilatation
Directly Toxic |
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IL- 6 is released by
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Macrophages
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TNF is released by
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Macrophages
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IL-1 is released by
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Macrophages
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TNF/IL-6/IL-1 Result in
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Acute Phase Response
(Activates EC's Fever NO Synthesis) |
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Lactoferrin/Transferrin are made by
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Macrophages
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Lactoferrin/Transferrin cause
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Binding of iron to starve pathogen
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Hagemen Factor is made by
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Liver (found in plasma)
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Complement is made by
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Liver (found in plasma)
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Bradykinin is made by
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Liver (found in plasma)
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Coagulation/Fibrinolytic Pathways is made by
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Liver (found in plasma)
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Bradykinin Causes
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Pain
Vasodilation ↑ Permeability |
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Hagemen Factor Causes
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Kinin
Clotting Fibrinolytic Complement Cascade |
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Complement Causes
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MAC (Membrane Attack Complexes)
Chemotactic Degranulation Factors |
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Coagulation/Fibrinolytic Pathway causes
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Coagulation
Thrombosis |
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Function of CD59
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Prevents MAC Forming on Self Cells
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CD 31 Used
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Diapedesis
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IL-8 used as
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Chemoattractant
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Diapedesis of Cells uses chemoattractants:
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IL 8
C5a |
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For Tight Binding in Cell Migration
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LFA-1 on Neutrophil
ICAM-1 on Activated Endothelial Cells |
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IL 2 Causes
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↑ Th1 + Th2
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IL 15 Causes
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↑Th1 and Memory Cells
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IL 12 Causes
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T Cell → Th1 Cell
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Opsonins in Complement
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C3b
iC3b |
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Chemotactics in Complement
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C4a
C3a C5a |
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Immune response stimulating fragments in Complement
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C3d (key for transition to secondary response)
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Regulatory proteins on self cell membrane for complement
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CD59
CD35 |
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Fibroblasts activate acute phase response with:
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TNF α
il-1β il 8 il 6 |
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Platelets and mast cells activate APR with:
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TNF α
il-1β |
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Infection activates APR with
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LPS
Muranic Acid dsRNA glycans |
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Cortisol will act to increase
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IL-1 (will eventually decrease it)
IL-6 |
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IL 4 Acts to
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↑Th2
↓ TNF ↓ il 1 ↓ il 8 |
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IL 10 Acts to
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↑IL-1Ra (will mop up IL1)
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IL 6 Acts to
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B Cells → Plasma Cells
Stem Cell Differentiation ↑ growth factors ↑ haematopoiesis ↑ acute phase response |
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CXCL 12 Receptor is
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CXCR4 on haemopoietic progenitors cells.
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CXCL 12 is used to
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Recruit haemopoietic progenitors cells to Bone Marrow
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B Cells express what to activate Th cells
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MHC Class 2
CD 80 CD 86 |
