Diclofenac

Diclofenac has been used (as the sodium salt) for topical treatment of AK since the 1990s (Rivers and McLean, 1997). The rationale for the use of this non-steroidal anti-inflammatory drug is the over expression of the cycloxygenase-2 enzyme in AK and SCC compared with normal cells (Buckman et al., 1998). In studies with SCC cell cultures, the commercial preparation, Solaraze™, when diluted to 0.2-0.3% was observed to promote apoptosis in certain sensitive cell lines (Fecker et al. 2010). Although sodium hyaluronate is included in the commercial gel formulation (Solaraze®), the precise function of this component remains unclear (Table 2). Systemic absorption of diclofenac from Solaraze™ has been reported but comparator studies with other diclofenac…

The Pros and Cons of Joint Injuries, Joint Trauma, and Joint Conditions Treated with Cortisone Should osteoarthritis, tendinitis, bursitis and other joint conditions be treated with cortisone, and to what extent should treatment take place? Skeletal problems are intertwined in treatment before cortisone treatments are administered. There are several treatments besides cortisone, such as massage, chiropractic, physical therapy, and natural remedies. One can measure quality by how safe it is…

98% of India’s vulture population was attributed to the popular veterinary drug Diclofenac. Diclofenac is a no steroidal anti-inflammatory drug used to reduce inflammation in cattle and other livestock to which vultures are highly allergic as it causes liver failure. (Taggart, 2007) As a result, feral dogs had a sudden abundant source of carcasses to feed on as they have replaced vultures as the main scavengers. Not only did feral dog population numbers explode as a result of the absence of…

The researchers compared both biologically produced manganese oxides and chemically produced manganese oxides for the oxidation of diclofenac. Because biologically produced manganese oxides are known to have high specific surface areas and high catalytic reactivity, this substance offers higher rates of oxidation for diclofenac when compared to chemically produced manganese oxides.² If biologically produced manganese oxides prove to completely eliminate diclofenac from the water supply, the…

SYSTEMS FOR CONTROLLED DELIVERY OF DICLOFENAC SODIUM [N.B: Authors' details blinded by Pro Journals for Review] ABSTRACT The formulation and evaluation of Diclofenac sodium from liposomes, niosomes and nanoemulsion are analyzed. The release profiles of Diclofenac sodium were almost similar in all the formulations. It is found that 85% of Diclofenac sodium diffused out from the colloidal systems within 8hrs and practically all the drug was released within 12hrs. In addition to this…

carbamazepine, diclofenac, ibuprofen, and sulfamethoxazole. The residues presented by these pharmaceutical pollutants are proving to negatively…

Results Table 1 showed that oral administration of Diclofenac sodium at 150mg/kg.b.w. resulted in a significant increase in renal tumor necroses factor -α (TNF-α), nitric oxide (NO) and thiobarbaturic acid reactive substances (TBARS) compared to the normal control group (p< 0.01). Rat receiving extract of any of the two doses of cranberry extract used in this study (75 and 150mg/kg.b.w.) showed a significant decrease in renal TNF-α, NO and TBARS compared to the group that received Diclofenac…

No. Amount Present in µg/ml Amount Found in µg/ml Amount Found in % SER DCL SER DCL SER DCL 1. 10 50 O9.90 50.00 99.00 100.00 2. 10 50 09.87 50.20 98.70 100.40 3. 10 50 10.00 49.90 100.00 101.80 4. 10 50 09.90 50.20 99.00 100.40 5. 10 50 10.10 50.00 101.00 100.00 6. 10 50 09.87 50.10 98.70 100.20 Table 3: Statistical Validation of Pure Drugs Drug Mean* (%) Standard Deviation* Co-efficient of Variation* (% R.S.D.) Standard Error* SER 99.40 0.9186 0.9241 0.3773 DCL 100.46 0.6772 0.6740…

was incubated with egg albumin in controlled experimental condition and subjected to determine absorbance to evaluate the anti-inflammatory activity. Diclofenac sodium was used as the standard/ reference drug. Result: This study revealed that the concentration dependent inhibition of protein (egg albumin) denaturation by the different extract. The effect of standard drug (Diclofenac sodium) was found to be less than that of test extract. Conclusion: From the present study it…

muscle aches/cramps/weakness, dizziness or light headedness, frequent headaches, memory loss, poor balance, tingling, depression, excessive thirst, heat/cold intolerance, frequent urination and urinary urgency. On examination of the wrist, range of motion is restricted with palmar flexion, dorsiflexion, ulnar deviation, radial deviation, supination and pronation. Movements are painful with dorsiflexion, ulnar deviation, radial deviation, supination and pronation. There is tenderness to palpation…