Previous studies has clarified the role of inflammation in mature atherosclerosis plaque rupture and acute ischemia (3). This suggests that targeting specific …show more content…
The curcumin`s beneficial effects on various inflammatory and degenerative diseases (e.g. Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy, cerebral injury, cardiovascular disease, cancer, allergy, asthma, bronchitis, colitis, rheumatoid arthritis, renal ischemia, psoriasis, diabetes, obesity, depression, fatigue and AIDS) have been well established(8-11). Although curcumin doesn’t seem to be toxic to animal and human, but its bioavailability is poor (12, 13). Curcumin moderates several inflammatory factors in cardiac tissue including: NF-κB, CRP, AP-1, myeloperoxidase enzyme (MPO), MMP-9. Il-1, Il-6, IL-8, IL-10, monocyte chemoattractant proteine-1 (MCP-1) and TNF-α in cardiovascular tissues (14). These mediators are the main cause of plaque rupture and ACS. Also literature suggests the protective role of curcumin in hyperlipidemia and myocardial infarction (15, 16).
Regarding that the role of inflammatory mediators is now clear in plaque rapture and that the present secondary preventions are not ideal, this study is set up to suggests curcumin as a secondary prevention for ACS considering its plaque stabilizing