At present a variety of [99mTc] based tracers are being used for skeletal metastasis diagnosis. Radiolabeled phosphonates are of an utmost interest in nuclear medicine for metastasis evaluation as well as for therapeutic application as many prevalent tumors are associated with metastasis. Bone targeting radiopharmaceuticals labeled with β emitters, administered systemically represents an acceptable adjuvant to external beam therapy for bone pain palliationin condition of osteoblastic bone metastasis. It has been reported that bone pain from metastatic conditions occurs very oftenly in patients with malignancies in organs such as prostate, breast and lung. Various pathophysiological interactions between host and tumor cells which leads to osteoclastic and osteoblastic lesions results into metastasis. The whole pathophysiological process of bone metastasis is mediated by various factors such as parathyroid hormone (PTH), cytokines and various tumor derived factors. Bone metastases in its initial stage are often clinically undiagnosable; however in later stages can lead to serious outcomes, such as distress, sudden injury in bon and hypocalcaemia. Bone pain caused by metastasis is often considered as a particular type of
At present a variety of [99mTc] based tracers are being used for skeletal metastasis diagnosis. Radiolabeled phosphonates are of an utmost interest in nuclear medicine for metastasis evaluation as well as for therapeutic application as many prevalent tumors are associated with metastasis. Bone targeting radiopharmaceuticals labeled with β emitters, administered systemically represents an acceptable adjuvant to external beam therapy for bone pain palliationin condition of osteoblastic bone metastasis. It has been reported that bone pain from metastatic conditions occurs very oftenly in patients with malignancies in organs such as prostate, breast and lung. Various pathophysiological interactions between host and tumor cells which leads to osteoclastic and osteoblastic lesions results into metastasis. The whole pathophysiological process of bone metastasis is mediated by various factors such as parathyroid hormone (PTH), cytokines and various tumor derived factors. Bone metastases in its initial stage are often clinically undiagnosable; however in later stages can lead to serious outcomes, such as distress, sudden injury in bon and hypocalcaemia. Bone pain caused by metastasis is often considered as a particular type of