Aromatic rings are very unique and therefore can follow very specific reactions in order to add select substituents to its ring. One of those types of reactions is referred to as Friedel-Crafts a reaction, to main sub-categories is Friedel-Crafts Alkylation and Friedel-Crafts Acylation. Both of these types of reactions involve electrophilic aromatic substitution and are work with deactivated rings (Friedel-Crafts Alkylation, 2010). In Friedel-Crafts Alkylation there is usually a secondary or tertiary alkyl halide (Cl) and a Lewis acid (AlCl3). The purpose of the Lewis acid is to create a carbocation, which is the electrophile. After the aromatic ring attacks the electrophile and the two bond the removed chloride atom then removes a proton from
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Cap the test tube and place in steam bath for 10 minutes and then follow with second TLC and if ferrocene is still present heat for 10 more minutes or until ferrocene no longer appears. Then cool the mixture in ice followed by the addition of 0.5 mL of water drop-wise. Then neutralize mixture using 3M sodium hydroxide, verify with litmus paper, collect product with Hirsch funnel and wash it with water. After drying product weight it, test melting point, and obtain proton NMR. The experimental melting point of Acetyl Ferrocene is 82-85°C, whereas the literature melting point is 85-86°C. The slight deviation can be one of two reason, either when the melting point was conducted the product was still slightly moist or that there are impurities present in the final product. The theoretical yield for the experiment is 0.114 g, but the actual yield is 0.055 g making the percent yield 58%. The TLCs that were conducted help keep track of the reaction because identify what compound were present at the time in terms of whether the starting material was still reacting and if the product formed. Rf1 represents the ferrocene, Rf2 has two values one for the product and one for the remaining starting material, and Rf3 represents just the product because the starting material was used up. The proton NMR helps verify that
Cap the test tube and place in steam bath for 10 minutes and then follow with second TLC and if ferrocene is still present heat for 10 more minutes or until ferrocene no longer appears. Then cool the mixture in ice followed by the addition of 0.5 mL of water drop-wise. Then neutralize mixture using 3M sodium hydroxide, verify with litmus paper, collect product with Hirsch funnel and wash it with water. After drying product weight it, test melting point, and obtain proton NMR. The experimental melting point of Acetyl Ferrocene is 82-85°C, whereas the literature melting point is 85-86°C. The slight deviation can be one of two reason, either when the melting point was conducted the product was still slightly moist or that there are impurities present in the final product. The theoretical yield for the experiment is 0.114 g, but the actual yield is 0.055 g making the percent yield 58%. The TLCs that were conducted help keep track of the reaction because identify what compound were present at the time in terms of whether the starting material was still reacting and if the product formed. Rf1 represents the ferrocene, Rf2 has two values one for the product and one for the remaining starting material, and Rf3 represents just the product because the starting material was used up. The proton NMR helps verify that