Reactive oxygen species (ROS) and nitric oxide (NO) play an important role in mediating cell damage during IRI(7, 8). …show more content…
Interest in the inflammatory response to IRI has led to the identification of multiple inflammatory mediators, including leukocytes, leukocyte adhesion molecules and cytokines. Neutrophils are the inflammatory cells, which produces abundantly ROS during IR injury. Renal IR causes tissue injury by oxygen radicals and oxidative stress caused by an imbalance between production of ROS and the antioxidant capacity(9). Myeloperoxidase (MPO) is found in neutrophils and catalyzes the formation of hypochlorous acid (HOCl), a toxic agent to cellular components and initiates oxidative