term1 Definition1term2 Definition2term3 Definition3
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Which is most potent
A
What is potency
how much it will take to achieve max response
Which is high affinity which is low
What does simple occupancy theory of drug action state
More R --> More intense response
Law of mass action
Affinity is directly related to potency
What does it mean if somehting has Kd of 10^-6 M
that when [D] = 10^-6 M, 50% of R is occupied
Units of k1 and K-1
k1 = /s
k-1 = /M s
For D + R --> DR
Kd =
[D][R]
[DR]
3 Factors governing Drug Specificity
Molecules are not spherical
Steric Hinderance
Electrostatic interactions
T/F Dobutamine has only B1 agonist activity
F; partial alpha antag for + isomer
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