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25 Cards in this Set
- Front
- Back
The hypothesis that overactive dopaminergic transmission in the CNS causes psychosis is known as the ____.
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Dopamine Hypothesis.
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An increase in transmission occurs in the (mesolimbic/mesocortical) system in schizophrenia.
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mesolimbic
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A decrease in transmission occurs in the (mesolimbic/mesocortical) system in schizophrenia.
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mesocortical
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Name some positive symptoms associated with schizophrenia.
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delusions, hallucinations, disorganized behavior, catatonic behavior
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Which system are positive symptoms associated with?
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mesolimibic
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Name some negative symptoms associated with schizophrenia.
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affective flattening, alogia and avolition
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Which system are negative systems associated with?
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mesocortical
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Which group of receptors is the mesolimbic system associated with?
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D2
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Which group of receptors is the mesocortical system associated with?
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D1
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Which receptors are included in the D1 class of receptors?
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D1, D5
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Which receptors are included in the D2 class of receptors?
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D2, D3, D4
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Which group of receptors (D1 or D2) is associated with stimulatory effects?
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D1
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Which group of receptors (D1 or D2) is associated with inhibitory effects?
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D2
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What amino acid is dopamine synthesized from?
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Tyrosine!
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What are two major enzymes that play a role in dopamine degradation?
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MAO and COMT
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Name some D1 antagonists.
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chloropromazine, haloperidol, clozapine, olanzapine
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Name some D2 antagonists.
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chlorpromozine, haloperidol, spiperone, sulpride, risperidone, clozapine, olanzapine
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Where are D1 receptors located?
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cortex, limbic system, basal ganglia, hypothalamus
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Where are D2 receptors located?
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cortex, limbic system, basal ganglia, pituitary gland
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Name some EPS.
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Muscle spasms, tremors, tics, restlessness
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Which group of antipsychotics are EPS associated with?
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Typical antipsychotics
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What are two theories for why atypical antipsychotics don't exhibit EPS?
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1) They also have 5-HT2 anatagonism.
2) They don't bind to D2 receptors as tightly as typical antipsychotics. |
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What was the initial antipsychotic drug discovered?
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Chlorpromazine (Thorazine)
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What two scaffolds do typical antipsychotics combine?
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TCA and piperazine scaffolds.
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What are the two primary scaffolds for atypical antipsychotics?
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1. Benzodiazepines (& isosteres)
2. Arylpiperazines (& isosteres) |