Influenza is made up of enveloped virions that further made up of eight segmented, single-stranded, negative RNA genomes (Bourmakina and García-Sastre, 2005). Influenza is then broken down further to three categories; A, B, or C, which is determined by the antigenic differences in their structural components nucleoprotein and matrix protein (M1) (Bourmakina and García-Sastre, 2005). Both nucleoproteins and MI proteins are crucial to the survival of the virus. In Influenza A’s RNA, it’s genomes call for 9 structural and 2 nonstructural proteins (Noda, 2011). In Influenza B’s RNA, it’s genomes call for 10 structural and 1 nonstructural protein (Noda, 2011). Of these three categorizes of Influenza, Influenza A is then broken down into …show more content…
Inside the virions and in hot infected cells, during the last stages of virus replication, the M1 protein will interact with the viral ribonucleoproteins (vRNPs). vRNPs consist of viral RNA molecules, many nucleoproteins copies, and three subunits of the viral polymerase that are at the ends of the viral RNAs holding it together (Samji, 2009). The nucleus of the infected host cell is where transcription and replication of the influenza virus genome occur. On the other hand virus particles assemble in the plasma membrane of the host cell (Bourmakina and García-Sastre, 2005). The MI protein also will link with the cytoplasmic tails of the glycoproteins found within the plasma membrane of the host cell (Samji, 2009).
In Influenza A, M1 protein has an important role virus budding (Samji, 2009). The morphology of the Influenza A virus can be drastically affected by mutation within the M1 protein (Noda, 2011). The M1 protein will be expressed within human cells through the virus budding process. The M1 protein displays a specific amino acid sequence that shows similar qualities and functions as the budding designs and techniques found within retroviruses matrix protein (Noda, …show more content…
Orthomyxoviridae contains virions that are filamentous or in spherical shapes, and usually 80-120mm long in diameter (Noda, 2011). The virion’s envelope is covered with nucleocapsids that are helical shaped and 6-9mm long (Noda, 2011). They are made up of single stranded-segmented RNA. Specific to Orthomyxoviridae virions, the nucleoproteins antigens all the members of the family are common to all the virions (Ritter, 2009). The nucleocapsids, hemagglutinin, and neuraminidase are generated in the nucleus of the host-infected cell (Ritter, 2009). During the budding stage of the viral replication is when mutation will occur, which causes the epidemics that result from the Influenza A and B virus in humans (Noda, 2011). Influenza C specifically lacks a neuraminidase (Noda,