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14 Cards in this Set
- Front
- Back
Age-Related Change for:
Myocytes |
Dec number, inc size; inc fibrocytes
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Age-Related Change for:
LV Stiffness |
Inc (dec compliance)
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Age-Related Change for:
LV Wall Thickness |
Inc
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Age-Related Change for:
Systemic Vascular Resistance |
Inc
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Age-Related Change for:
Left Atrium |
Inc
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Age-Related Change for:
LV Diastolic Passive Filling |
Dec (atrial contraction more important)
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Age-Related Change for:
Maximum Heart Rate |
Dec
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Age-Related Change for:
Maximum Cardiac Output |
Dec
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Age-Related Change for:
Max Volume of Oxygen |
Dec
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Age-Related Change for:
Vasodilation with exercise |
Dec
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Diastolic Changes with Age
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Failure of LV relaxation reduces passive filling, thus more filling generated by atrial contraction
Accordingly, rapid heart rates that shorten diastole compromise cardiac output Interference with atrial contraction (AFib) further reduces diastolic filling Active filling also impaired (Ca2+ handling) |
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Blood Pressure Changes with Age
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Systolic pressure much more accountable than diastolic pressure for things like stroke and coronary heart dz
Widening Pulse Pressure increases with age (not just systolic) is primary villain in producing disease states associated with elevated BP |
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Arterial Changes with Aging
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Inc'd vascular stiffness
Inc pulsatile load (inc systolic and pulse pressures) |
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What aging-related changes increase risk for cardiovascular diseases?
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Dec CV reserve, LV stiffness-->CHF (PEF)
Dec baro-reflex sensitivity, autonomic dysfn-->syncope BP and PP changes-->HTN, stroke Sinue node atrophy, dysfn-->AF Inc FIBRINOGEN, Factors V, VIII, IX-->Thrombosis Valvular Sclerosis, Ca2+-->Murmurs, stenosis Atherosclerosis-->Inc ischemia, AMI |