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11 Cards in this Set
- Front
- Back
Resistance
mechanisms |
4 biochemical mechanisms
production of enzymes which inactivate the antibiotics alteration of the target of the antibiotic metabolic bypass preventing access of the antibiotics to its site of action |
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Resistance
Types |
Acquired resistance
Inherent resistance |
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Choice of Antibiotics
|
infective organism (esp. HAI)
antimicrobial susceptibility host factor |
|
Lab testing: most helpful in urgent situation...
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Gram stain
Gram +ve: blue Gram -ve: pink |
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Types of penicillin
|
Benzylpenicillin
b-lactamase resistant forms Broad-spectrum penicillins Extended spectrum penicillins Reversed-spectrum penicillins |
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Benzylpenicillin
|
Gram +ve
not b-lactamase resistant |
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b-lactamase resistant forms
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Flucloxacillin
purely gram +ve only |
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Broad-spectrum penicillins
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Gram +ve and gram -ve
|
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Extended spectrum penicillins
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Pseudomonads
|
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Reversed-spectrum penicillins
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Aztreonam
Gram -ve |
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Penicillins
|
cidal
beta lactams, bind to penicillin binding protein and inhibit transpeptidation target: narrow spectrum gram positive Resistance: destroyed by beta lactamase hydrolyzed in stomach side fx: allergic reaction, seizures (high iv doses) |