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39 Cards in this Set
- Front
- Back
Eicosanoids are derived from:
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Arachidonic acid
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phospolipase A1 cleaves at the ___ postition
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sn1
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Arachidonic acid is cleaved from phospholipids by:
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phospholipase A2 or C through the activity of di and mono-acyl glycerol lipases
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phospholipase C cleaves at the ___ position.
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sn1 and sn2 yielding DAG
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Phospholipase A2 cleaves the:
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sn2 position of a phospholipid
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DAG lipases and MAG lipases make _____ from DAG
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free fatty acids
(arachadonic acid) |
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Lipoxygenase
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converts arachidonic acid to leukotrienes
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phospolipase A2 cleaves at the ___ position
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sn2
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Cyclooxygenase
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converts arachidonic acid to prostaglandins
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from arachadonic acid, cyclooxygenase makes
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all the prostaglandins and TXA2 (vasoconstrictor)
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Cytochrome P450
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converts arachidonic acid into epoxides
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lipoxygenase
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makes leukotrienes from arachadonic acid
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What is the function of prostaglandins
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Prostaglandins function as mediators of inflammation and pain.
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glucocorticoids inhibit _______ metabolism.
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eiconasoid
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What type of receptors to prostaglandins bind to:
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G protein coupled receptors
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Isoprostane synthesis is initiated by ROSs. The level of Isoprostane in the urine can be used as marker of ____?
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oxidative stress
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cox-1 is a _____ enzyme, where cox-2 is a _____ enzyme.
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constitutive, inducible
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What is thromboxane?
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Thromboxane is synthesized in the platelets and is a potent vasoconstrictor and activator of platelets.
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What are the five cardinal signs of inflammation?
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-calor (heat)
-rubor (redness) -tumor (swelling) -dolor (pain) -functio laesio (loss of tissue function) |
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acetominephin irreversible inhibts_____
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cox-3
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What is Protacyclin?
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Protacyclin is synthesized from endothelial cells and is an inhibitor of coagulation.
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aspirin irreversibly inhibts ______
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cyclooxygenase
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Asprin inhibits the enyzmatic activity of:
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cyclooxygenase
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endocannabinoids are endogenous ligands for ______ receptors
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cannainoid
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(True or False) Asprin will decrease TXA2 synthesis?
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TRUE
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___ is the most abundant prostaglandin, and is synthesized from_____.
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PGE2, omega-6
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(True or False) COX-1 is an inducible enzyme.
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FALSE
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arachadonic acid is predominantly released from phospholipids by which enzyme?
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phospholipase A2
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(True or False) COX-2 is an inducible enzyme.
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TRUE
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non-steroidal anti-inflammatory drugs inhibit_______.
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cyclooxygenase
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What are Leukotrienes?
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Leukotrienes are important regulators in the inflmmatory response and bind to G protein coupled receptors. Leukotrienes are important in Asthma.
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eicosanoids
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prostaglandins, thromboxanes, leukotrienes & epoxides; control cellular function in response to multiple signals i.e. Inflammation
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(True or False) Isoprostanes are produced when arachidonic acid underoges free radical damage.
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TRUE
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all eicosanoids are derived from_______.
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arachadonic acid
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(True or False) Isoprostanes are elevated during reperfusion injury.
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TRUE
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Anadmaide is an eicosanoid that can act as an agonist for which receptor?
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The cannabinoid receptor
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Glucocorticoids inhibit eicosanoid synthesis by blocking:
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Phospholipase A2
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Overproduction of _____ is the primary cause of inflammation in asthma patients.
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leukotrienes
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Overproduction of _____ is the primary cause of inflammation in asthma patients.
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leukotrienes
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