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67 Cards in this Set
- Front
- Back
What 3 diseases are associated with McLeod's syndrome (absence of Kx)?
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1) Chronic Granulomatous Disease
2) Retinitis Pigmentosa 3) Muscular Dystrophy |
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what is the minimum h/h to donate an autologous donation?
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11g/dL/33%
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What drug has indefinite deferral?
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Etretinate (Tegison) Psoriasis drug
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Why are blood or products washed?
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1) IgA deficiency
2) Neonatal Autoimmune Thrombocytopenia (NATP) 3) Repeted Febrile nonhemolytic transfusion reactions (FNHTR) |
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What race has the most Lewis A/B antibodies?
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African Americans
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The presence of H. pylori aids this blood group in attaching to gastric epithelium:
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Lewis B
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Anti I is associated with what conditions?
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1) Mycoplasma Pneumonia
2) Cold agglutanin disease 3) Lymphomas |
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Little i is associated with what condition?
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Mono
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Paroxysmal Cold Hematuria is associated with what?
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Donath-Landsteiner biphasic hemolysin
ANTI P TgG colds coat lyses warm |
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What is important about the Donath-Landsteiner test
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IgG coats cold lyses warm..
Anti P biphasic hemolysin |
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What are the "R" Weiner haplotypes?
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R1= DCe
R2=DcE R0= Dce Rz= DCE |
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What are the "r" Wiener haplotypes?
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r'= dCe
r"= dcE r= dce ry= dCE |
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What antigen is associated with the most significant HDN?
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Rh(D)
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What blood group involves the most significant cause of HDN/
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ABO
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What factor is not present in cryo?
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Factro XII (12) AKA prekallikrein or HMW kinonogen
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How does glycerol affect RBC's?
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in vivo/vitro hemolysis. Water moves into the cells.
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WHat causes deglycerolized blood to form an insoluble jelly-like mass?
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Donor has SS trait
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What is the most common form of HDN/
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GROUP O mother anti
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What factors are increased in stored whole blood?
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H+ and K+
Lactate and hemoglobinn are also increased (hemolysis) |
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What is decreased in stored blood?
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2,3 DPG
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What are three ways to detect acquired B antigen?
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1) Reacetylation using acetic anhydride.
2) Monoclonal anto B should be negative 3) Use of lectins griggonia simplicofoli and phaseous lunatis. |
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What are the naturally occurring antibodies?
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Lewis I/i P M A N
LIPMAN Basically the carbohydrate antibodies (IgM) |
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What lectin agglutinates with H antigen?
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Ulex europaeus
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What is the deferral for history of CJD versus travel to CJD areas?
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Both are indefinite
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What RBC antigen is decreased by enzyme activity?
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MNS
Duffy |
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What RBC antigens do not cause HDN?
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PIL
P1 Le A/Le b I/i |
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What RBC antigen is not affected by enzymes?
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KELL KELL KELL
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What are compatible fluids fro transfusion?
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1) Normal saline
2) ABO compatible plasma 3) 5% albumin |
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Cryoprecipitate is made by:
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Thaw FFP at 4 degrees C.
Remove supernatant This leaves cryo-reduced plasma |
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Cryoreduced plasma has less of the following factor:
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vWF because it stays with precipitate.
Given in TTP because less multimers. |
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What RBC antigen confers P.vivax resistence?
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Fy(a-/b-)
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What solutions are incompatible with blood transfusions?
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1) 0.45 % saline
2) D5W 3) TPN: shrinkage 4) Antibiotics 5) Lactated ringers |
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Why is lactated ringers incompatible with blood transfusion?
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It contains 3mEQ Ca/L that counters citrate in blood products
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Contraindications to platelet administration include:
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1) TTP/HUS
2) HIT type II |
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Which has more H antigen A1 or A2?
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A2
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What is the H antigen density on RBC's from most to least?
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O>A2>B>A2B>A1>A1B>Oh
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What lectin differentiates between A1 and A2?
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Dolichos Biflorus agglutinates A1
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Enzyme enhanced RBC antigens include:
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ARK (A rotten Kid)
ABO Rh KIDD |
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What is the deferral for Hepatitis B IgG administration?
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12 months
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What are the protein antigens?
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Rh (D)
KIDD KELL S/s Duffy |
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What antigens must an individual be positive for if they are f antigen positive?
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c and e in the cis position
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What effect do thiol reagents (DTT,ZZAP) and enzymes have on Kell system antigens?
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Kell system ags are destroyed by thiol reagents (DTT,ZZAP) but untouched by enzymes alone.
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What is the acceptable temperature range for the transport of red blood cells?
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1-10C for 24 hours
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if a patient is C,D and e antigen positive (negative for c and E antigen), what is their most probable Rh genotype?
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R1R1
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McLeod phenotype
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In the Kell blood group, what phenotype is associated with all this: absence of Kx, markedly decreased Kell system ags, lack of anti-Ku, hemolytic anemia with acanthocytes, and association with X-linked CGD?
ACANTHOCYES and X-LINKED CHRONIC GRANULOMATOUS DISEASE) |
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Saliva neutralizes:
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H, Le a
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Hydatid cyst fluid and pigeon egges neutralize:
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P1
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Breast milk neutralizes
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I
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What is the formula for calculating RhIg administration?
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Vials of RhIg=(maternal whole blood mL)X (% fetal cells in moms blood)/ 30
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Rh null (Bombay phenotype) is associated with :
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Hereditary stomatocytosis
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Anti-P is associated with:
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Paroxysmal cold hemaglobinuria (PCH) and syphilis.
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What is th eshelf-life for sline washed, thawed, or deglycerolized RBC's?
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24 hours
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Thawed FFP has a shelf life of:
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24 hours
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Thawed plasma has a shelf life of:
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5 days
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Pooled platelets have a shelf life of:
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4 hours
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What are the 4 most common antibodies that cause dlayed HTR?
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JKa
E D C |
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Mixed field reactions are expected with :
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Lutheran
Sid A3 post BMT |
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Intravascular hemolysis is caused by:
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ABO
Kidd P |
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The presence of which antibody is implicated in spontaneous abortions?
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Anti P1 and and PP1-Pk
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Which antigens show dosage?
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Kidd (Jk)
Duffy (Fy) Rh (DCE) MNS |
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Where are class I HLA antigens found?
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all nucleated cells and platelets
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Where are class II HLA antigens found?
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1) B cells
2) macrophages 3) activated Tcells |
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Class I genes are found at what LOCI?
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HLA-A
HLA-B HLA-C |
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Class II genes are found at what LOCI?
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HLA-DR
HLA-DP HLA-DQ |
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Application of a tattoo has a deferral of:
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12 months
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What are clinical differences between a vasovagal vs a hypovolumic reaction?
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VASOVAGAL = decreased heart rate
hypotension syncope nausea Hypovolumic has hepretension |
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Bein incarcerated for more than 72 hours requires a deferral of:
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12 months
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