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32 Cards in this Set
- Front
- Back
what is the first organ system to reach functional maturity
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cardiovascular
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major cardivascular development is complete by what week kof gestation
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8 weeks gestation
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what is the critical period of human heart development
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between 20-50 days gestation
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heart tube beings to beat at what day
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day 21-day 22
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what happens during the 4th week of vascular system development
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looping of vascular system
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bilaminar germ disc consists of what two layers
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ectoderm
endoderm |
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trilaminar disc consists of what three layers
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ectoderm
endoderm mesoderm |
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mesoderm differentiates into
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precardiac mesoderm (precursor of most of the mature heart cells)
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precardiac cell fate is determined by
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timing and entry point through primitive streak
TGF-beta family of molecules in endoderm |
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cardiogenic crescent is formed by
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precardiac mesodermal cells that migrate and join lateral plate mesoderm
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arteries and veins are derived from
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angiogenic clusters of mesoderm (blood islands)
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knockout of what gene prevents cardiovascular system development
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tinman
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morphologic organization of cardiogenic crescent
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atrium
ventricle conotruncus cells first distinguisable phenotypically as precardiac cells cells destined to contribute to specific areas of mature heart are segregated to specific locations |
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lateral plate mesoderm splits into
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splanchnic mesoderm
somatic mesoderm |
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splanchnic mesoderm gives rise to
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precardiac cells
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somatic mesoderm gives rise to
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pericardium
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paired cardiac tubes are formed from
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myocardial and endocardial precursors
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three layers of initial paired cardiac tubes
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myocardium on outside
cardiac jelly in middle endocardium on inside |
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2 cell layers of primitive heart tube
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myocardium (outside)
endocardium (inside) |
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3 cell types of primitive heart tube
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endocardial endothelial cell
atrial myocyte ventricular myocyte |
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endocardial endothelial cells form
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cushion cells (without them wont have separation between chambgers)
line surfaces of heart |
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atrial myocyte
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muscle cells of atria
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ventricular myocyte
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muscle cells of ventricles
pukinge fibers |
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five segments of primitive heart tube
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truncus anteriosus
outlet inlet atrium sinus venosus |
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five segments of primitive heart tissue
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truncus anteriosus
outlet inlet atrium sinus venosus |
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truncus anteriosus forms
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aorta
pulmonary artery trunks |
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outlet forms
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apical right ventricle
inlet right ventricle both outlets |
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inlet forms
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apical left ventricle
inlet of left ventricle |
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atrium
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atrial appendages
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sinus venosus
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superior vena cava
inferior vena cava smooth venous portions of both atria |
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venus pole anchored to
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septum transversum (bottom)
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aterial pole anchored to
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ventral aoritc arches (top)
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