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25 Cards in this Set
- Front
- Back
What does cM stand for?
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centimorgans
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What does m.u. stand for?
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map units
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What was the first human disease gene to be successfully mapped by positional cloning?
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Huntington disease (HD)
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Southern blotting
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A process where researchers separate DNA fragments by electrophoresis, blot the separated fragments to a special filter paper, and then examine the bands
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TDF is?
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testes-determining factor
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copasetic
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very good; excellent; completely satisfactory
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incontrovertible
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incontestable, undeniable, unquestionable
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controvert
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to argue against; dispute; deny; oppose
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transgenic plant/animal
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an individual carrying a transgene
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What are the symptoms of cystic fibrosis?
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Abnormally viscous secretions in the lungs, pancreas, and sweat glands
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vetting
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to examine or treat in one's capacity as a veterinarian or as a doctor
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positional cloning
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the process that enables researchers to obtain the clone of a gene without any prior knowledge of its protein product or function. It uses genetic and physical maps to locate mutations responsible for particular phenotypes
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linkage map
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depicts the distances between loci as well as the order in which they occur on the organism
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transgenic technology
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the tools for inducing a specific change in a gene and confirming that this change causes the predicted phenotype. Transgenic technology includes experimental methods that allow scientists to add laboratory-constructed DNA sequences to the genomes of animals or plants
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transgene
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any piece of foreign DNA that researchers have inserted into the genome of an organism
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targeted mutagenesis
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alters the DNA sequence of a particular gene or regulator region in a predetermined way.
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LOD score analysis
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logarithm of the [od]ds analysis; stastistical method for determining the likelihood that two or more loci are linked together on the same chromosome
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phase of linkage
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haplotype confirgurations
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knockout mice
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mice homozygous for an induced mutation in a targeted gene; the mutation destroys (knocks out) the functional gene
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phenocopy
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a change in phenotype arising from environmental agents that mimic the effects of a mutation in a gene.
Phenocopies are not heritable because they do not result from a change in a gene |
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quantitative trait loci (QTLs)
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loci that control the expression of continuous traits
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haplotype is short for?
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haploid genotype
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haplotype
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a specific combination of two or more DNA marker alleles on the same homolog
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linkage disequilibrium
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when alleles at separate loci are associated with each other at a significantly higher frequency than would be expected by change
may be indicative of common ancestry |
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paternity
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the state of being a father; fatherhood
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