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28 Cards in this Set
- Front
- Back
- 3rd side (hint)
The pluripotential stem cell give rise to ...
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lymphoid and myeloid stem cells
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the earliest hematopoietic precursor cells, which can differentiate into either hematopoietic or marrow stromal cells , have the following cell surface marker?
which key markers are not yet present? |
CD34
CD38, HLA-DR |
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cell surface marker that denotes erythroid differentiation
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CD71 (early erythroid marker)
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which cytokine is the ligand for proto-oncogene c-mpl?
what is its role in hematopoiesis? |
this is thrombopoietin, the primary regulator of platelet production
it is required for full maturation of megakaryocytes |
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which cytokine stimulates eosinophils?
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IL5
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which cytokine is referred to as 'stem cell factor' or 'steel factor' and act synergistically with GM-CSF and IL-3 to stimulate myeloid, erythroid and lymphoid progenitors?
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kit ligand, the ligand for the tyrosine kinase receptor c-kit
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Megaloblastic erythroid maturation, nuclear maturation lags behind cytoplasmic maturation. T or F
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True
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How do eosinophils contribute to fibrosis in Hodgkin's?
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Eosinophils secrete tumor necrosis factor which promotes fibrosis
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person with a 2,3-DPG level of 4.4miicromol/g is noted to have a Hb O2 satutrtiopn of 70% at a pO2 of 40mmHg. he is given 2,3-DPG to raise his level to 11.6micormol/g. At 40 mmHg, what is his new Hb saturation?
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55%, this is helping him offload oxygen to his tissues
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reactions which form porphobilinogen and the final product heme?
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aminolevulinic acid --(ALA-dehydrase)--porphobilinogen
protoporphyrin IX + Fe2+---(ferochelatase)---Heme |
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what is the normal mechanism by which senescent erythrocytesare culled from circulation...what bichemical change takes place?
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sialic acid residue on the glycophorin molecule is lost and asialoglycophorin is seen as an antigen. Autoantibodies bind to the red cell and process it for removal
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Corrected reticulocyte index ( reticulocyte production index) gives a clinically useful assessment of a patient's response to anemia because it accounts for the degree of anemia as well as the expected maturation time of reticulocytes released early from the marrow into the peripheral blood. The formula for RPI?f
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RPI=(pt retic% x pt Hct x1)/ ( nml retic % x nml Hct x maturation time)
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Azurophilic granules mark the transition in neutrophil maturation from the myeloblast to the promyelocyte. What is contained in these granules?l
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Lysosomal enzymes --- acid hydrolases, acid phosphatase, beta- glucotandase, perioxidase( this is why we use the MPO stain for acute leukemias, and why M0 does not stain more than3%)
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What are the actions of eosinophilia cationic protein (ECP)?
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ECP shortens the coagulation time and alters fibrinolysis, inhibits lymphocyte proliferation and acts as a potent neurotoxin
mature eosinophils express CD16 and CD32 |
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principle growth factor for basophils? mast cells?
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IL3, ckit
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cell surface markers on monocytes and macrophages
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CD14, CD64 and CD68
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defineendomitosis as it applies to megakaryocyte maturation
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nuclear division without accompanying cytoplasmic division; in megakaryocytes it results in ploidies fron 2N to 64N
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cell markers for the progenitor (pro)B cell
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the pro B cell is CD19 and TdT positive
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intracytoplasmic mu heavy chains without surface immunoglobin are characteristic of what phase of B cell development?
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pre B cell
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what 2 key events in T cell functional development occur in the thymic medulla?
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in the medulla self reactive T cells are culled out so they will not attack in an autoimmune fashion; the T cell receptor rearranges to generate diversity
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NK cell markers?
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CD16 and CD56 are helpful markers for NK cells
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where in the heme biosynthetic pathway is zinc protoporphyrin synthesized
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zinc protoporphyrin is synthesized at the end of the heme biosynthetic pathway from protoporphyrin IX by the action of ferrochelatase ; if no iron is available ferrochelatase will substitue zinc in its place
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chromatographic techniques are now used to screen for PBG in cases of suspected porphyries, the old Watson -Schwartz test lacked sufficient sensitivity to be used reliably
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test now used to screen for porphobilinogen in cases of suspected porphyrias?
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which of the porphyrias is suggested..
53yoM chronic alcoholic who has had longstanding porphyria. minor trauma has caused several erosions on his forearm, and sun exposure hase lead to vesicle formation on his face. the only abnormality is urine uroporphyrin of 200microgram in 24hrs |
PCT
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which of the porphyrias is suggested..
4yof wearing long sleeves and a large sun hat on a warm day. She smiles, her teeth are pink-red. Her urine is red pigmented and has 2000microgram of urine UP. |
CEP
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which of the porphyrias is suggested..
14yom holding his stomach and acting in an agitated way in the waiting room, his mom was with him. She had tubal ligation after he was born becauseshe could not tolerate oral contraceptives. His 24 hour urine amino levulinic is 500mg, porphobilinogen is 205. total bilirubin today is 3.5mg/dL and alkaline phosphatase is 130IU/L. Fecal protoporphyrin is 600micrograms over 24hrs |
AIP
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32yof from south africa . she has a few few skin lesions on her forearm and face. she has required tranquilizers twice in her life during acte attacks. she is in the clinic today because she has been feeling suspicious for the past couple of days. fecal protoporphyrin is 10,000 micrograms over 24hrs, UP is 420micrograms
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VP
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