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21 Cards in this Set
- Front
- Back
B-ALL
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CD 10, 19, 20, TdT+, sIg-
t(12;21), t(9;22) Kids Vincristine, prednisone, daunorubicin, asparaginase |
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T-ALL
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CD1,2, cytCD3, TdT+
Adolescent males |
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CLL/SLL
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CD5, 23, 19, 20
Del 11, 13, and tri 12 60+ Chlorambucil, fludarabine, cyclophosphamide, rituximab |
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DLBCL
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CD 10, 19, 20, BCL6 (blocks differentiation).
t(14;18)-DLBCL a progression from follicular lymphoma OR EBV assoc w/ immunodef. All ages, 60+ common Tx: same as CLL, anti-CD20 aby |
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Follicular lymphoma
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CD 10, 19, 20, sIg, BCL6 and BCL2
t(14;18): BCL6-IgH 50+ Same as CLL |
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Burkitt's Lymphoma
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CD 10, 19, 20, sIg, BCL6. NO BCL2
t(8;14): c-MYC-IgH Kids and young adults |
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Mantle cell
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CD 5, 19, 20, sIg (23 negative)
t(11;14): cyclin D1-IgH Older males Poor px |
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Marginal zone
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CD 10, 19, 20
Assoc w/ inflammation Tx by removing enciting agent (H. pylori) |
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Hairy Cell
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CD 19, 20, 25, 103, 11c
TRAP: tartrate resistant acid phosphatase Middle age white males. Splenomegaly, hypercellular BM, pancytopenia. Tx: gentle chemo, cladipine, pentostatin |
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Multiple myeloma
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Plasma cell markers. Bence-Jones protein, M protein, punched out lesions, amyloidosis.
t(11;14)-Cyclin D1-IgH t(4;14)-FGFR3-signals w/ cyclin D1 del 11q13-poor px IL-6->MIP1-alpha->NF-kB->RANKL->incr osteoclast activity Older adults, African descent DVd, thalidomide |
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Waldenstrom macroglobulinemia
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CD20, sIg, high levels monoclonal IgM. Heavy chains=light chains
Del at 6q Older adults Incurable, anti-CD20 aby, palliative plasmaphoresis |
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Adult T cell Leukemia/Lymphoma
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CD4+, cloverleaf nuclei
HTLV encodes TAX protein that activates NF-kB Japan, W. Africa, Caribbean Poor px, aggressive chemo |
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Mycosis fungoides
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CD4+, CLA, CCR4, CCR10, Sezary cells
Older pts, indolent at first. Progresses to Sezary dz (involves blood, BM, and skin) Poor px |
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Nodular sclerosis (HL)
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Most common HL, classical, CD 15, 30, PAX5, EBV NEGATIVE.
30's, M=F MOPP, ABVD, or combo |
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Mixed cellularity (HL)
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Classical. CD 15, 30, EBV+
Young OR old adult MALES MOPP, ABVD, or combo |
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Lymphocyte Rich (HL)
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Classical. CD 15, 30, EBV+
Males MOPP, ABVD, or combo tx |
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Lymphocyte Depleted (HL)
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CD 15, 30, and EBV+
Males MOPP, ABVD, or combo tx |
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Lymphocyte Predominant (HL)
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Non-classical. EBV negative, CD 20, BCL6 (NO CD 15, 30). Popcorn cells.
Males MOPP, ABVD, or combo tx |
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AML
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CD 33, 34
t(8;21) + inv(16)->CBF1alpha/CBF1beta fusion protein, blocks differ. Favorable px Inv(16)-MYH11, abnormal precursors block differ. Favorable t(15;17): RARalpha-PML. Intermediate px, tx w/ ATRA t(11q23; var)-histone/chromatin modifier. Iatrogenic, dismal px |
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CML
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CD34, low leuk alk phos
t(9;22): BCR-ABL fusion, constitutively active tyr-kinase Adults in 50's. 3 stages: chronic, acclerated, blast crisis. Insidious onset, serendipitous dx. Tx w/ imatinib in combo w/ hydroxyurea, kids get BMT |
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MDS
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Clonal stem cell that may develop into AML. Ineffective hematopoiesis.
May be idiopathic or secondary to tx (t-MDS). Dz of elderly (70's), hypercellular, dysplastic BM w/ ringed sideroblasts, megaloblastoid mutations, Pseudo-Pelger Huet cells. BMT for younger pts |