Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
45 Cards in this Set
- Front
- Back
Tetrodotoxin (TTX) mode of action
|
blocks voltage gated sodium channels
|
|
Tetraethylammonia (TEA)
|
blocks voltage gated potassium channels
|
|
what is the formula for the time constant (how long it takes for the membrane to be 63% depolarized)
|
T=RmCm
time constant= membrane resistance times membrane capacitance |
|
formula for length constant (63% the total distance a subthreshold charge would spread)
|
gamma= square root dRm/4Ri
d-diameter Rm=membrane resistance Ri=cytoplasm resistance |
|
Tetrodotoxin (TTX) mode of action
|
blocks voltage gated sodium channels
|
|
Tetraethylammonia (TEA)
|
blocks voltage gated potassium channels
|
|
what is the formula for the time constant (how long it takes for the membrane to be 63% depolarized)
|
T=RmCm
time constant= membrane resistance times membrane capacitance |
|
formula for length constant (63% the total distance a subthreshold charge would spread)
|
gamma= √ dRm/4Ri
d-diameter Rm=membrane resistance Ri=cytoplasm resistance |
|
Curare mode of action
|
competitive inhibitor of ACh at nicotinic receptors; used so we can view the EPSP in experiments
|
|
Neostigmine mode of action
|
inhibits Acetylcholinesterase;
makes EPSP larger and longer in duration; used to treat Myasthenia gravis |
|
Myasthenia Gravis
|
autoimmune disease that decreases number of ACh receptors at the NMJ making muscles weak
|
|
NT released by the inhibitory interneuron in the spinal cord
|
glycine
|
|
NT released by a sensory neuron onto a motor neuron in the spinal cord
|
glutamate
|
|
the most common NT with inhibitory actions
|
GABA
|
|
netrins and semaphorins
|
cell surface or secreted proteins important in axon pathfinding
|
|
agrin
|
a nerve derived factor released into the synaptic cleft which causes ACh receptors in the postsynaptic cell to cluster at the NMJ
|
|
colchicine mode of action
|
depolymerizes microtubules crucial for axonal transport
|
|
what is different about microtubule associated proteins in the dendrite vs. those in the axon
|
they have higher MW
|
|
vinblastine
|
similar to colchicine; disrupts microtubules
|
|
synapsin
|
a vesicle binding protein that when activated by Calcium causes vesicles to move toward the active zone of the synapse
|
|
botulism toxin mode of action
|
block synaptic transmission by interfering with vesicle docking binding proteins
|
|
synaptotagmin
|
binds Calcium and causes secretory vesicle fission (probably)
|
|
SNAP-25, Syntaxin, and VAMP
|
vesicle binding proteins that form a trimeric complex that causes a secretory vesicle to be "primed" for fission
|
|
n-sec-1
|
a protein that must be displaces (mech. unknown) before a secretory vesicle can bind to dock w/ the plasma membrane
|
|
botulism toxin
|
inhibits ACh release by preventing vesicle docking
|
|
black widow spider venom
|
stimulates excessive ACh release
|
|
curare
|
blocks nicotinic ACh receptors (competitive inhibition)
|
|
atropine
|
blocks muscarinic ACh receptors
|
|
sweat glands and piloerector muscles
|
places where postsynaptic sympathetic neurons release ACh instead of NE; binds muscarinic receptors
|
|
isopropylfluoroesters
|
irreversible AChE inhibitors; nerve gases and insecticides
|
|
eserine
|
a reversible AChE inhibitor used clinically
|
|
N-methyl-D-Aspartate
|
a synthetic glutamate agonist
|
|
Strichnine
|
blocks the inhibitory glycine receptor leading to hyperexcitation and inability to relax the diaphragm
|
|
Benzodiazepines (valium, librium)
|
bind the gamma subunit of the GABAa receptor to enhance GABA binding
|
|
Barbiturates
|
bind the alpha and beta subunits of the GABAa receptor to enhance GABA binding
|
|
Picrotoxin
|
blocks ion flow through the GABAa receptor
|
|
Reserpine
|
inhibits uptake of Monoamine NT's into their storage vesicles
|
|
Isoproterenol
|
sythetic agent that is an agonist of NE and E at Beta-receptors (inhibitory)
|
|
cocaine and tricyclic antidepressants
|
inhibit the reuptake proteins for DA NE and 5-HT
|
|
Amphetamines
|
cause reuptake pumps to reverse and pump Monoamine NT's into the extracellular space
|
|
HVA and DOPAC
|
DA metabolites used to measure DA function in CNS
|
|
MHPG
|
NE metabolite used to asses NE function in CNS
|
|
VMA
|
NE metabolite used to measure autonomic activity
|
|
Metanephrine
|
used to asses activity of adrenal medulla or tumor
|
|
TMI
|
a histamine metabolite
|