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37 Cards in this Set
- Front
- Back
6 RFs for endometrial ca
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obesity
chronic anovulation nulliparity early menarche late menopause family ca hx |
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2 (non-histological) kinds of endometrial ca
___ kind has better prognosis ___ kind is more common |
E dependent (type I)
E independent (type II) type I type I |
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4 histological kinds of endometrial ca
most common is ___ |
endometroid
mucinous clear cell papillary serous endometroid |
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___ is the most important prognostic factor for endometrial ca
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histologic grade
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2 cancers which constitute familial hx RFs
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endometrial
HNPCC |
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HNPCC association with endometrial ca is aka ___
this includes ___ (4) |
Lynch 2 syndrome
CRC endometrial ca ovarian ca breast ca |
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main sx of endometrial ca
this occurs early/late |
postmenopausal bleeding
early |
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late menopause as RF is specifically ___
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after 52 yo
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12 months of OCP use does ___ to endometrial ca risk
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reduces by 50% for 10 years
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2 kinds of histopath paramaters used to evaluate endometrial hyperplasia
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cells
glands |
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cells are graded based on ___
glands are graded based on ___ |
atypia present/absent
shape simple/complex |
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___ is the defining histopath characteristic of premalignant biopsies
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cellular atypia
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4 parts of initial workup for postmenopausal bleeding
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biopsy
TVUS bloodwork pap smear |
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bloodwork for postmenopausal bleeding includes ___ (5)
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CBC
TSH PRL FSH CA-125 |
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in Pap smear for postmenopausal bleeding you should look for ___
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endometrial cells
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3 options for endometrial biopsy
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pipelle
D&C hysteroscopy |
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D&C advantage
D&C disadvantage |
definitive dx
requires anesthesia |
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high CA-125 indicates ___
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extrauterine spread
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on US, endometrial stripe of postmenopausal woman should be ___
unless ___, in which case it should be ___. |
<5 mm
she's on HRT <8 mm |
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stage 0 endometrial ca is ___
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atypical hyperplasia
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stage 1 endometrial ca is present in ___
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uterine corpus only
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stage 2 endometrial ca is present in ___
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uterus
cervix |
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stage 3 endometrial ca is present in ___
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pelvis
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stage 4 endometrial ca is present in ___
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outside of pelvis
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main form of spread for endometrial ca is ___
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direct invasion
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tx for endometrial hyperplasia without atypia (2)
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depot medroxyprogesterone acetate (DMPA)
repeat biopsy in 3 months |
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DMPA is aka ___
it is a ___ analogue |
depo-provera
progesterone |
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tx for atypical endometrial hyperplasia
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total hysterectomy
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T/F: cx is removed in total hysterectomy
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true
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___ is an option for patients with stage 0 disease who want to preserve fertility
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conservative (medical) tx
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before starting conservative tx, you must do ___ in order to ___
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D&C
rule out cancer |
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conservative tx for stage 0 disease (2)
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megestrol
norethindrone |
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tx for stage 1 endometrial ca (3)
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TAH
BSO pelvic washings |
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tx for stage 2+3 endometrial ca (3)
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TAH
BSO pelvic washings LN dissection |
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tx for stage 4 endometrial ca
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palliative
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2 groups of LNs dissected for endometrial ca
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pelvic
para-aortic |
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___% of endometrial ca is dxed at stage 1
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73
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