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10 Cards in this Set
- Front
- Back
pathophys of abo incompatibility
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mom is O baby is A or B
mom has IgG against A and B from food source, and IgG crosses placenta --> hemolysis in utero and intrapartum |
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labs to eval neonatal abo incompatability
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get neonatal type and DAT
if DAT +, follow bili and if bili high, check cbc and retic +/- smear for spherocytes |
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pathophys of rh incompatibility
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mom is rh - and has IgG vs D antigen
IgG crosses placenta and destroys Ab coated RBCs RBCs --> hemolysis and splenic sequestration --> anemia and high output CHF |
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how to prevent rh incompatability
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give mom RhoGAM at 28 wks and also post-partum
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how does RhoGAM work
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its an Ig vs D Ag, it binds to any D Ag in mom's circulation from fetus and gets destroyed by the spleen
this way, mom never makes the IgG vs D Ag |
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sx of congenital rubella infx
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cataracts/glaucoma
heart defects (PDA) CNS (deaf, MR, behavior) growth restriction radiolucent bone dz HSM blueberry muffin rash |
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what is the risk assoc with 1mary syphilis in utero
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40% risk of SAB, stillbirth or perinatal death
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what is the risk assoc with 2ndary syphilis in utero
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6-100% risk of transmission
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sx of congenital syphilis
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mucocutaneous lesions
snuffles rash HSM LAD osteochondritis pseudoparalysis hemolysis thrombocytopenia |
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when do sx occur in congenital syphilis
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can occur within the 1st week of life, and may be nml at birth
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