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17 Cards in this Set
- Front
- Back
agonist
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agent that is capable of binding with receptors and producing a response
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antagonist
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agent that blocks the response of another drug
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dose-response relationship
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the way a patient responds to varying doses of a drug
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efficacy
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the maximal response that can be produced from a particular drug
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frequency distribution curve
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a graphic representation of the actual number of patients responding to a particular drug action at different doses
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idiosyncratic response
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unpredictable and unexplained drug reaction
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intrinsic activity
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the ability of a drug to bind to a receptor and produce a strong action
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median effective dose (ED50)
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the dose of a drug required to produce a specific therapeutic response in 50% of a group of patients
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median lethal dose (LD50)
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the dose of a drug that will kill 50% of a group of animals
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median toxicity dose (TD50)
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dose that will produce a given toxicity in 50% of a group of patients
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partial agonist
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medication that produces a weaker, or less efficacious, response than an agonist
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pharmacodynamics
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study of the mechanisms of drug action and how the body responds to drugs
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pharmacogenetics
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the study of genetic variations that give rise to differences in the way patients handle medications; branch of pharmacology that examines the role of genetics in drug response
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potency
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the strength of a drug at a specified concentration or dose
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receptor
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the structural component of a cell to which a drug binds to produce a response
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second messenger
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cascade of biochemical events that initiates a drug's action by either stimulating or inhibiting a normal activity of the cell
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therapeutic index
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the ratio of a drug's LD50 to its ED50
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