Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
major opportunistic infxns in early posttransplant period (1-6 months)
|
HPV, CMV, EBC, Hep A,B,C, HIV
|
|
CMV
|
EGD if epigastric pain in posttransplant
|
|
Solid organ transplants long term consequence
|
non-hodgkin's B cell lymphoma
|
|
tacrolimus vs cyclosporine
|
both nephrotoxic
tacrolimu superior for improving graft suvival but increased DM, GI AE and seizures |
|
Mycophenolate mofetil
|
blocks guanosine nucleotides required for DNA; inhibits B and T cell proliferation
|
|
indications for splenectomy in ITP
|
3-6 months of steroids to maintain plt >30,000
|
|
Posttransplant lymphoproliferative disorder
|
EBV
MC in SB & lung transplants highest incidence w/n 1st year fevers/night sweats/LAD |
|
Treatment of PTLD
|
rituximab (anti-CD 20Ab)
|
|
Management of tertiary hyperPTH
|
2-5% after renal transplant
fatigue, bone pain, osteo elevated Ca, PTH Tx subtotal parathyroidectomy or total with auto-transplant |
|
Secondary hyperPTH
|
develops in ESRD after HD
resolves w/n 1 year of transplantation |
|
Acute rejection
|
T-cell mediated
related to organ-host human leukocyte antigen disparity treatment can save graft in 90-95% a/w with increased risk of chronic rejection |
|
Acute cellular rejection of solid organ transplants
|
activation of recipient T lymphocytes by graft-derived antigens
|
|
Acute rejection
|
usually occurs between 1-6 weeks after transplantation
|
|
Side effects of cyclosporine
|
posttransplant DM
HTN nephropathy hyperlipidemia |
|
Side effects of tacrolimus
|
similar risk of of nephropathy
less risk of hyperlipidemia/HTN |
|
Daclizumab
|
against CD25 (IL 2 receptor alpha chain)
|
|
mycophenolate mofetil
|
inhibits purine synthesis (replaced azathioprine)
|