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23 Cards in this Set
- Front
- Back
How do you show acetylcholinesterase degrades acetylcholine? |
Dumpster of acetyl-cola bottles |
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Acetylcholinesterase inhibitors increase synaptic concentration of ACh |
Knocked over dumpster with cola bottles rolling out |
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How do you remember the ending for these drugs? |
Stigma on dumpster, for -stigmine |
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How is it shown there is increased effects of ACh at neuromuscular junction (increased effect at sicotinic receptors)? |
Skeletal muscle brick wall with motor end plate |
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What disease is treated with acetylcholiesterase inhibitors, how is it shown in sketchy? |
The "Gravis gang" Myesthenia gravis |
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What is a good longterm acetylcholinesterase inhibitor for myethenia gravis, how is it shown? |
Community PRIDE work cleaning up "gravis" graffiti Pyridostigmine |
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What is a good symptomatic treatment for myesthenia gravis? |
Neon sign Neostigmine |
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What are quarternary amines? Give examples |
Quarternary - Do not penetrate CNS 1a) Pyrostigmine 1b) Neostigmine 1c) Edrophonium Shown as quarters only on phone booth |
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Explain the tensilon test and what drug is used |
Test using edrophonium Tests to see if patient is being under or over-treated since it has such a short half-life Positive: Reverses muscle weakness in undertreated myesthenia graves patients Negative: Exacerbates cholinergic crisis Shown with a high/low tense phone wire |
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What inhibits nicotinic ACh binding at neuromuscular junction? |
Curare crayons in outlet Tubocurarine Pancuronium Cisatracurium |
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What inhibits neomuscular blockade? |
Neon sign (neostigmine) owner kicking out kid with crayons |
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What irriversibly causes blockade, potentiating effects of Choline? |
Succinylcholine (ACh agonist) Phase-1 Worker getting shocked, irriversibly damaging endplate, which SUCKS |
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What acetylcholinesterase inhibitor can be used to treat urinary retention? |
Neon sign owner with hose Neostigmine |
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What can be used to treat atropine overdose? |
Phys Ed building Physostigmine Phys ed teacher taking artist that drew: Alice in wonderland holding nightshade graffiti on the wall (Atropine) |
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What is Jimson weed? |
Gym sign Naturally occurring form of atropine |
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What |
Can be reversed by physostigmine |
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What drug can reverse peripheral and central cholinergic blockade? |
Physostigmine Brain on drugs poster indicating it can pass into CNS |
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What can be caused by acetylcholinesterase inhibitor toxicity? |
Diarrhea Urination Miosis Bronchspasm Bradycardia Guy working out using Lacrimation dumbells by a weak nicotine Salivation kid showing flaccid paralysis Sweating |
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What typically causes acetylcholinesterase inhibitor toxicity? |
Thiols sprays (Insecticides) Parathion, malathion, echothiophate Shown by toxic waste guy with green gas |
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What is used to treat insecticide poisening? |
Pralidoxime Closing the lid on toxic spray |
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What reverses central and peripheral muscarinic toxicity because Pralidoxime can't pass into CNS? |
Atropine Alice on poisen dumpster |
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What is aging of organophosphae-cholinesterase complex? |
It is the irreversible binding, making pralidoxime ineffective Old guy spraying isn't working too well |
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What acetyly cholinesterase is useful for alziemers? |
Galantamine, Rivastigmine, Donepezil Alzheimer's gala: Reverse the stigma Elderly are done with puzzle |