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47 Cards in this Set
- Front
- Back
Blood Cell formation
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hematopoiesis
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Most important WBC in immune system response, binds to basic dyes
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Neutrophill
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WBC involved in allergic reaction
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basophils
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WBC important in expelling parasitic worms
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Eosinophilis
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Blood cells are stimulated to differentiate by
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colony-stimulating factor
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Circulates in blood
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monocyte
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when it enters liver, spleen, lymph nodes and lungs
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macrophage
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specailized cells that engulf and digest cellular debris
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Phagocyte
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cytokine induced activities.
greater____capacity, adhesion molecule_____ change, movement to ______, secretion of _____ ________. |
greater killing capacity, adhesion molecule expression chaange, movement to new territory, secretion of inflammatory factors.
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inflammation works by
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lysing microbes to disrupt membrane
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What are the three types of wBC
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Granulocytes, mononuclear phagocytes, and lymphocytes
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what binds to surface to start omplement fixation
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c3b
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The process of marking microbes for phagocytosis
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Optonization
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Causes lysis of foreign cells by using complexes c6 c7 c8 and c9
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MAC (membrane attack complex)
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Quickly and easy form of alternative pathway. Relies of binding of C3b
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Alternative Pathway
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pathway that is activated by mannan binding lectins
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Lectin Pathway
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Activation that requires antibodies that interact with complement c1
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classical pathway
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Leakage of phagocytes from blood vessels
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diapedesis
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programmed cell death
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apoptosis
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strongest indicator of bacterial infection
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fever
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Temperature regulation center of body responds to fever inducing substances called
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pyrogenes
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normal flora produce_______, which poison competing bacteria
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bacteriosins
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C3a and C5a cause what outcome?
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inflammation, changes in endothellial cells that effect permeability
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cells that have responsibilities for mediating adaptive immune responses
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lymphocytes
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small part of an antigen that engages responders
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Epitope
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where do b cellls undergo developmental stages, t cells?
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bone marrow, thymus
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pathogen materials are transported from infection site via
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dendritic cells
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primary lymphoid organs
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bone marrow, and thymus
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Salt? example
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Skin associated lymphoid tissue.
Armpits |
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malt? examples
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mucosal associated lymphoid tissue
breast, oral, respiratory, gastrointestinal, and tract issues |
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secondary lymphoid organs/tissues
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tonsills, spleen
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antibody response is what type of response
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HUMORAL RESPONSE
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Humoral response is....
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extracellular
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antibodies bind to the antigen to preven the pathogen or toxin from binding to receptor on cell
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neutralization
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anibodies bind to flagella and pili to prevent motility and attachment
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immobilization
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binding of antibodies to multiple antigen molecules to form large antibody-antigen complexes for a phagocytic cell
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agglutination
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specific complement protein attatches to Fc regions of antibodies on cell surface to activate complement__________.
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cascade
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ADCC
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Antibody dependent cellular cytotoxicity
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First antibody to respond to infection
5-13% circulation monomer units joined together at constant rate |
IgM
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dominant antibody
80 to 85 ciruclation |
IgG
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antibody abundant in secretion of muscosal tissues
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IgA
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barely detectable
bound to basophils important mediator in allergic responses important in eliminating parasites |
Ige
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<1% CIRCULATION
monomer found on surface of mature B cells |
IgD
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when does initiation of antibody response begin
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when antigen binds to b cell receptor
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B cells respond quicker at first, this is called ______ maturation
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affinity
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T helper cells do what
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divide to form plasma cells and b cells
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what happens when memory b cells differentiate to plasma cells?
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antibodies of mass produciton
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