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15 Cards in this Set
- Front
- Back
3 examples of MAOIs?
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1. Phenelzine sulfate (Nardil)
2. isocarboxazid (Marplan) 3. tranylcpromide (Parnate) |
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moa of MAOIs?
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interfere w/ monoamine oxidase, which allows for increased conc. of NTs (E, NE, S) in synaptic space, causing stabilization of mood
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2 indications for MAOIs?
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1. depression
2. chronic pain syndromes |
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When might hypertensive crisis occur?
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MAOI + tyramine-containing foods
MAOI + OTC meds containing ephedrine, pseudoephedrine |
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List of foods containing tyramine? (15)
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1. aged cheese
2. bologna 3. pepperoni 4. salami 5. figs 6. bananas 7. raisins 8. beer 9. chianti red wine 10. liver 11. yogurt 12. herring 13. yeast 14. sour cream 15. pickled products |
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4 potential side effects of MAOIs?
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1. photosensitivity
2. weight gain 3. sexual dysfunction 4. orthostatic hypotension |
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Are MAOIs the first-line drugs for depression?
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no
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Which drugs canNOT be combined w/ MAOIs? (4)
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1. SSRIs
2. antihypertensive meds (caution) 3. CNS depressants 4. alcohol |
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When should a pt d/c the MAOI prior to general anesthesia?
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d/c MAOIs 10 days prior to general anesthesia
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What do MAOIs do to one's seizure threshold?
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they LOWER the seizure threshold
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Which GU side effect should you monitor for in a pt taking an MAOI?
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urinary retention
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Which drugs should be avoided while a pt is taking an MAOI? (3)
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1. caffeine
2. amphetamines 3. antihistamines |
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How long does it take for an MAOI to work?
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3-4 wk
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When can a pt who has finished taking MAOIs start taking a TCA?
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can take a TCA until 3 wk stopping MAOI inhibitors
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What are the signs of a hypertensive crisis? (5)
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1. headache
2. sweating 3. palpitations 4. stiff neck 5. intracranial hemorrhage |